16297-10-2Relevant academic research and scientific papers
The reactivity of isocyanides with pentafluoropyridine
Irani, Motahereh,Mehrabi, Hossein,Poorfreidoni, Alireza,Ranjbar-Karimi, Reza
, p. 1369 - 1375 (2021/10/19)
Reactivity of some isocyanides with pentafluoropyridine under basic conditions in dry dimethyl sulfoxide was investigated. The reaction of pentafluoropyridine with toluenesulfonylmethyl isocyanide (TosMIC) was less selective, but the reactions of other is
Preparation and reactions of 2,3,4,6-tetrafluoropyridine and its derivatives
Coe, Paul L.,Rees, Anthony J.
, p. 45 - 60 (2007/10/03)
A reliable route to 2,3,4,6-tetrafluoropyridine has been established starting from the readily available 3,5-dichlorotrifluoropyridine by halogen exchange under controlled conditions to give 3-chlorotetrafluoropyridine and its subsequent hydrodechlorination using hydrogen over palladium on alumina at 250-270°C. The formation and reactions of the 3-lithio derivative have been studied with the aim of obtaining 3,4-disubstituted trifluoropyridines. Routes to such materials have been developed and their conversion to deazapurine derivatives as potential substrates for the generation of anti-sense nucleosides are reported.
