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16297-19-1 Usage


4-Iodo-2,3,5,6-tetrafluoropyridine is a halogenated pyridine derivative with the molecular formula C5H2F4IN. It features a pyridine ring with four fluorine atoms and one iodine atom attached, known for its strong electron-withdrawing properties. 4-iodo-2,3,5,6-tetrafluoropyridine is commonly used as a building block in organic synthesis and pharmaceutical research, playing a crucial role in the creation of complex organic molecules.


Used in Organic Synthesis:
4-Iodo-2,3,5,6-tetrafluoropyridine is used as a building block for the synthesis of complex organic molecules, leveraging its strong electron-withdrawing properties to facilitate various chemical reactions and the formation of desired products.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-Iodo-2,3,5,6-tetrafluoropyridine is utilized as a key intermediate in the development of new drugs. Its unique structure and reactivity contribute to the design and synthesis of potential therapeutic agents with improved pharmacological properties.
Used in Agrochemical Development:
4-Iodo-2,3,5,6-tetrafluoropyridine is also employed in the agrochemical sector for the creation of novel compounds with selective and reactive properties. This contributes to the development of more effective and targeted pesticides and other agrochemical products.
Safety Considerations:
It is important to handle 4-iodo-2,3,5,6-tetrafluoropyridine with care due to its potential health and environmental hazards. Proper management and safety measures should be implemented to minimize risks associated with its use in research and industrial applications.

Check Digit Verification of cas no

The CAS Registry Mumber 16297-19-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,2,9 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 16297-19:
121 % 10 = 1
So 16297-19-1 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name 2,3,5,6-Tetrafluoro-4-iodopyridine

1.2 Other means of identification

Product number -
Other names 4-iodo-tetrafluoropyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16297-19-1 SDS

16297-19-1Relevant articles and documents

Halogen Bonds of Halotetrafluoropyridines in Crystals and Co-crystals with Benzene and Pyridine

Schwabedissen, Jan,Trapp, Pia C.,Stammler, Hans-Georg,Neumann, Beate,Lamm, Jan-Hendrik,Vishnevskiy, Yury V.,K?rte, Leif A.,Mitzel, Norbert W.

, p. 7339 - 7350 (2019)

The structures of the three para-substituted halotetrafluoropyridines with chlorine, bromine, and iodine have been determined in the solid state (X-ray diffraction). The structures of these compounds and that of pentafluoropyridine were also determined in the gas phase (electron diffraction). Structures in the solid state of the bromine and iodine derivatives exhibit halogen bonding as a structure-determining motif. On the way to an investigation of halogen bond formation of halotetrafluoropyridines in the solid state with the stronger Lewis base pyridine, co-crystals of benzene adducts were investigated to gain an understanding of the influence of aryl–aryl interactions. These co-crystals showed halogen bonding only for the two heavier halotetrafluoropyridines. In the pyridine co-crystals halogen bonding was observed for all three para-halotetrafluoropyridines. The formation of homodimers and heterodimers with pyridine is also supported by quantum-chemical calculations of electron density topologies and natural bond orbitals.

Preparation of p-substituted tetrafluoropyridyl derivatives via the tetrafluoropyridylcopper reagent

Van Nguyen, Ba,Burton, Donald J.

, p. 144 - 154 (2012/03/27)

A new and improved preparation of 4-iodo-2,3,5,6-tetrafluoropyridine from pentafluoropyridine is described. This iodopyridine is utilized for the in situ preparation of the 4-tetrafluoropyridylcopper reagent, 1, via two methods. The first method involves metathesis of the 4-tetrafluoropyridylcadmium reagent with Cu(I)Br at room temperature. The requisite cadmium reagent was readily prepared in situ via reaction between 4-iodotetrafluoropyridine with acid-washed cadmium powder in DMF at room temperature. The second method involves the in situ reaction of 4-tetrafluoropyridyltributyl-phosphonium tetrafluoroborate with Na2CO3 and Cu(I)Br in DMF at room temperature. 1 readily undergoes reaction with allylic halides, vinyl iodides, aryl halides, acid chlorides and acetylenic iodides at room temperature to stereospecifically afford the corresponding 4-tetrafluoropyridyl derivatives. An alternative route to the alkyne derivatives was developed via the Pd(0) catalyzed reaction of 4-iodotetrafluoropyridine with 1-alkynes.

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