1629888-45-4

Basic information

• Product Name: 4-hydroxy-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide
• Synonyms: 4-hydroxy-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide
• CAS NO: 1629888-45-4
• Molecular Weight: 355.374
• Mol File: 1629888-45-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-hydroxy-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide(1629888-45-4)
• EPA Substance Registry System: 4-hydroxy-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide(1629888-45-4)

Safety Data

• Hazardous Substances Data: 1629888-45-4(Hazardous Substances Data)

Upstream product

• 604-50-2 glycosmicine 
• 28141-24-4 4-hydroxybenzoyl chloride 
• 1629888-39-6 1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carbothioamide 
• 119-68-6 N-Methylanthranilic acid 

Relevant articles and documents

Synthesis and antioxidant activity of novel quinazolinones functionalized with urea/thiourea/thiazole derivatives as 5-lipoxygenase inhibitors

In the present study, a series of novel quinazolinones functionalized with urea/thiourea/thiazole derivatives was synthesized and evaluated for their antioxidant and 5-lipoxygenase (5-LOX) inhibition activities. The newly synthesized compounds were characterized using 1H NMR, 13C NMR, IR, Mass spectra and elemental analysis. The antioxidant activities of the title compounds were evaluated using DPPH, superoxide, hydroxyl and nitric oxide radical scavenging assay in vitro. It is revealed from the antioxidant screening results that the compounds 3e, 5f and 6c manifested profound antioxidant potential. The synthesized compounds were screened for their 5-LOX inhibitory activity. Overall, 3e, 5f and 6c showed promising antioxidant and 5f showed 5-LOX inhibitory activity and may be used as the lead compounds in the future study.