1630067-58-1

Basic information

• Product Name: (R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-ol
• Synonyms: (R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-ol
• CAS NO: 1630067-58-1
• Molecular Weight: 266.337
• Mol File: 1630067-58-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-ol(1630067-58-1)
• EPA Substance Registry System: (R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-ol(1630067-58-1)

Safety Data

• Hazardous Substances Data: 1630067-58-1(Hazardous Substances Data)

Upstream product

• 1630067-57-0 (R)-1-(methoxymethoxy)but-3-en-2-ol 
• 70388-33-9 4-benzyloxybut-1-ene 

Downstream Products

• 1630067-66-1 methyl (2R,3S,4S)-3-[2-(benzyloxy)ethyl]-4-(prop-1-en-2-yl)-2-vinylpyrrolidine-1-carboxylate 
• 487-79-6 (-)-kainic acid 
• 1630067-74-1 (2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enoic acid 
• 1630067-75-2 (2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enamide 
• 1630067-77-4 methyl {(2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-en-1-yl}carbamate 
• 1630067-78-5 methyl {(2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-hydroxy-2-(2-methoxyphenyl)hex-4-en-1-yl}carbamate 
• 1630067-79-6 methyl (2R,3S,4S)-3-[2-(benzyloxy)ethyl]-4-(2-methoxyphenyl)-2-vinylpyrrolidine-1-carboxylate 
• 1630067-80-9 methyl (2S,3S,4S)-3-[2-(benzyloxy)ethyl]-2-(hydroxymethyl)-4-(2-methoxyphenyl)pyrrolidine-1-carboxylate 
• 1630067-81-0 methyl (2S,3S,4S)-3-(2-hydroxyethyl)-2-(hydroxymethyl)-4-(2-methoxyphenyl)pyrrolidine-1-carboxylate 
• 132785-33-2 MFPA 
• 1630067-84-3 (2R,3R,E)-3-[2-(benzyloxy)ethyl]-2-cyclopropyl-6-(methoxymethoxy)hex-4-enoic acid 
• 1630067-63-8 C₂₀H₃₁NO₃ 
• 1630067-60-5 (2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(prop-1-en-2-yl)hex-4-enoic acid 
• 1630067-76-3 C₂₄H₃₃NO₄ 

Relevant articles and documents

A unified strategy for kainoid synthesis

A unified strategy for kainoid synthesis was developed. The key features of the strategy involve a Claisen-Ireland rearrangement to construct the contiguous stereogenic centers and a palladium-catalyzed formation of the pyrrolidine ring with complete stereoselectivity. The present protocol has enabled rapid access to a wide range of kainoids with diverse types of substituents (alkenyl, aryl, and alkyl groups) at the 4-position of the pyrrolidine ring, starting from the common intermediate and appropriate acetic acid derivatives. To test the generality of the strategy, we have accomplished the syntheses of kainic acid, o-methoxyphenyl derivative (MFPA), and a novel cyclopropyl derivative (CPKA), using 3-methylbut-3-enoic acid, 2-(2-methoxyphenyl)acetic acid, and 2-cyclopropylacetic acid, respectively.