163008-81-9

Basic information

• Product Name: diphenylmethyl 7β-formamido-3-[(pyrazin-2-yl)methylthio]-3-cephem-4-carboxylate
• Synonyms: diphenylmethyl 7β-formamido-3-[(pyrazin-2-yl)methylthio]-3-cephem-4-carboxylate
• CAS NO: 163008-81-9
• Molecular Weight: 518.617
• Mol File: 163008-81-9.mol

Chemical Properties

• CAS DataBase Reference: diphenylmethyl 7β-formamido-3-[(pyrazin-2-yl)methylthio]-3-cephem-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diphenylmethyl 7β-formamido-3-[(pyrazin-2-yl)methylthio]-3-cephem-4-carboxylate(163008-81-9)
• EPA Substance Registry System: diphenylmethyl 7β-formamido-3-[(pyrazin-2-yl)methylthio]-3-cephem-4-carboxylate(163008-81-9)

Safety Data

• Hazardous Substances Data: 163008-81-9(Hazardous Substances Data)

Upstream product

• 59021-02-2 2-(mercaptomethyl)pyrazine 

Downstream Products

• 163009-31-2 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(pyrazin-2-yl)methylthio]-3-cephem-4-carboxylic acid 

Relevant articles and documents

Orally active cephalosporins. Part 3: Synthesis, structure-activity relationships and oral absorption of novel C-3 heteroarylmethylthio cephalosporins

A series of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3- (heteroarylmethylthio)cephalosporins was designed, synthesized and evaluated for antibacterial activity and oral absorption in rats. Antibacterial activity was markedly influenced by the structure of the heteroaromatic ring moiety. Oral absorption was influenced by the heteroaromatic ring moiety as well as by the arrangement of heteroatoms. Among these compounds, FK041 (2o), having a 4-pyrazolylmethylthio moiety, showed potent antibacterial activity against both Gram-positive and Gram-negative bacteria including Haemophilus influenzae. Further, it showed higher oral absorption than CFDN.