16303-61-0Relevant academic research and scientific papers
Ruthenium-catalysed conversion of 1,4-alkynediols into pyrroles
Pridmore, Simon J.,Slatford, Paul A.,Daniel, Aurélie,Whittlesey, Michael K.,Williams, Jonathan M.J.
, p. 5115 - 5120 (2007)
Various 1,2,5-substituted pyrroles have been synthesised from 1,4-alkynediols using a ruthenium catalysed isomerisation to give the corresponding 1,4-dicarbonyl compounds, which undergo in situ cyclisation to pyrroles in the presence of amine.
Synthesis of furans, pyrroles and pyridazines by a ruthenium-catalysed isomerisation of alkynediols and in situ cyclisation
Pridmore, Simon J.,Slatford, Paul A.,Taylor, James E.,Whittlesey, Michael K.,Williams, Jonathan M.J.
supporting information; experimental part, p. 8981 - 8986 (2009/12/27)
Alkyne-1,4-diols are readily available substrates which are isomerised to 1,4-diketones using Ru(PPh3)3(CO)H2/xantphos as a catalyst. In situ cyclisation into furans, pyrroles and pyridazines has been achieved under suitable conditions.
2,5-Disubstituted furans from 1,4-alkynediols
Pridmore, Simon J.,Slatford, Paul A.,Williams, Jonathan M.J.
, p. 5111 - 5114 (2008/02/09)
1,4-Alkynediols serve as readily available starting materials for isomerisation to 1,4-diketones, which can be converted in situ into the corresponding furans by acid-catalysed dehydration. A range of 2,5-disubstituted furans was prepared using the ruthenium-based catalyst Ru(PPh3)3(CO)H2 with Xantphos at 1 mol % loading.
Synthese de polyethers polycycliques. 1 Stereoselectivite de l'heterocyclisation d'alcools tetrahydrofurfuryliques γ,δ-ethyleniques par les sels mercuriques
Amouroux, Roger,Chastrette, Francine,Chastrette, Maurice
, p. 565 - 570 (2007/10/02)
The intramolecular oxymercuration of the 1-(2-tetrahydrofuryl)-4-penten-1-ols (5) by mercuric salts followed by reductive demercuration affords the 2-methyl-5-tetrahydrofuryltetrahydrofuran (9) as a mixture of cis and trans isomers in good yields.By using mercuric acetate, each isomer threo 5a and erythro 5b gives the trans isomer, 9d and 9b, respectively, as the major products.On the other hand, cyclization carried out with mercuric chloride are not stereoselective.
