16305-98-9Relevant academic research and scientific papers
T -BuOK-catalysed alkylation of fluorene with alcohols: A highly green route to 9-monoalkylfluorene derivatives
Fan, Jiang-Tao,Fan, Xin-Heng,Gao, Cai-Yan,Wang, Zhenpeng,Yang, Lian-Ming
, p. 35913 - 35916 (2019)
A simple, mild and efficient protocol was developed for the alkylation of fluorene with alcohols in the presence of t-BuOK as catalyst, affording the desired 9-monoalkylfluorenes with near quantitative yields in most cases.
Nickel-catalyzed synthesis of 9-monoalkylated fluorenes from 9-fluorenone hydrazone and alcohols
Fan, Jiang-Tao,Fan, Xin-Heng,Chen, Yong-Jie,Gao, Cai-Yan,Yang, Lian-Ming
, p. 2895 - 2902 (2019/08/12)
A practical protocol was disclosed for the nickel-catalyzed C-alkylation of 9-fluorenone hydrazone with alcohols using t-BuOK as the base, and 9-monoalkylated fluorene derivatives were obtained in good yields under the benign conditions.
Aldehyde/ketone-catalyzed highly selective synthesis of 9-monoalkylated fluorenes by dehydrative C-alkylation with primary and secondary alcohols
Chen, Jianhui,Li, Yang,Li, Shuangyan,Liu, Jianping,Zheng, Fei,Zhang, Zhengping,Xu, Qing
supporting information, p. 623 - 628 (2017/08/17)
By using aldehydes or ketones as the catalyst and screening CsOH out as the more effective base than KOH in many instances, an efficient 9-C-alkylation of fluorenes with alcohols was achieved to provide a green and practical method for general synthesis of the useful 9-monoalkylated fluorenes in high selectivities. This new method tolerates a wide range of substrates including activated and unactivated primary and secondary alcohols, thus solving the issues remaining in the field and largely broadening the diversity of the 9-monoalkylated fluorenes. Consequently, fine-tuning of the alkylated fluorenes was made possible to provide specific fluorene monomers for function-oriented polyfluorenes. Preliminary mechanistic studies revealed that the external carbonyl compounds can be quantitatively regenerated and recovered in the reaction cycle.
