1630956-01-2Relevant academic research and scientific papers
Three component synthesis of 2-oxindole via sequential Michael addition, intramolecular cyclization and aromatization
Boominathan, Muthusamy,Nagaraj, Muthupandi,Muthusubramanian, Shanmugam,Bhuvanesh, Nattamai
, p. 18549 - 18557 (2014/05/20)
An easy metal free access to the synthesis of medicinally promising 2-oxindole derivatives via a tandem enamine formation-Michael addition-regiospecific intramolecular cyclization-aromatization sequence promoted by trifluoroacetic acid has been described. This three component reaction is regiospecific with good yield and satisfactory atom economy.
