1630982-53-4Relevant academic research and scientific papers
Iron-catalyzed oxidative 1,2-carboacylation of activated alkenes with alcohols: A tandem route to 3-(2-oxoethyl)indolin-2-ones
Ouyang, Xuan-Hui,Song, Ren-Jie,Li, Jin-Heng
, p. 3395 - 3401 (2014/06/09)
Oxindoles are important heterocyclic compounds that are found in a wide range of pharmaceutical agents and natural products. A new oxidative tandem route to the assembly of 3-(2-oxoethyl)indolin-2-ones from N-arylacrylamides and alcohols has been established by using inexpensive and environmentally benign iron catalysts and peroxides. In the presence of Fe(OAc)2 and tert-butyl hydroperoxide, a variety of arylacrylamides underwent the oxidative 1,2-carboacylation reaction with alcohols to give the corresponding 3-(2-oxoethyl)indolin-2-ones in moderate to good yields. Copyright
