1630985-05-5Relevant academic research and scientific papers
Chiral phosphoric acid-catalyzed enantioselective three- component aza-diels-alder reactions of aminopyrroles and aminopyrazoles
Brioche, Julien,Courant, Thibaut,Alcaraz, Lilian,Stocks, Michael,Furber, Mark,Zhu, Jieping,Masson, Geraldine
supporting information, p. 1719 - 1724 (2014/06/09)
A highly stereoselective three-component Povarov reaction, catalyzed by (R)- and (S)-BINOL hydrogen phosphate, was achieved for the first time with aminopyrroles and aminopyrazoles as 2-azadiene precursors. A variety of aldehydes, enecarbamates, amino-substituted azines participated in the reaction to afford the tetrahydropyrrolopyridines and tetrahydropyrazolopyridines in good yields with excellent diatereo- and enantioselectivities. A stereochemical model is proposed to account for the observed absolute stereochemistry.
