163128-46-9Relevant academic research and scientific papers
CRTH2 MODULATORS
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Page/Page column 80-81, (2010/04/27)
Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I
A radical cyclisation based cyclopentenone annulation of allyl alcohols
Srikrishna,Viswajanani,Sattigeri
, p. 2975 - 2983 (2007/10/03)
A four-step cyclopentenone annulation reaction of allylic alcohols employing a 5-exo-trig radical cyclisation reaction of mixed allyl methyl ketals of bromoacetone as the key step is described. The annulated product 12b obtained from 2,3-dimethylcyclohexenol has been further elaborated into (±)-epibakkenolides employing a 5-exo-dig radical cylisation reaction based α-spiro-β-methylene-γ-butyrolactone annulation methodology.
Cyclopentaannulation of Allyl Alcohols via a Radical Cyclisation Reaction. Total Synthesis of 4-Epibakkenolide-A
Srikrishna, A.,Viswajanani, R.,Sattigeri, J. A.
, p. 469 - 470 (2007/10/02)
A four step cyclopentaannulation methodology starting from allyl alcohols using 5-exo-trig radical cyclisation as the key reaction, and its application to the total synthesis of 4-epibakkenolide is described.
