163136-67-2Relevant academic research and scientific papers
Pyridothiadiazines
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, (2008/06/13)
The invention relates to a compound selected from those of formula (I): STR1 in which A, R 1, R 2 and R 4 are as defined in the description,and medicinal products containing the same which is useful for treating a pathology related to dysfunctioning of gl
Synthesis and structural studies of a new class of heterocyclic compounds: 1,2,4-Pyridothiadiazine 1,1-dioxides, pyridyl analogues of 1,2,4-benzothiadiazine 1,1-dioxides
De Tullio, Pascal,Pirotte, Bernard,Dupont, Leon,Masereel, Bernard,Laeckmann, Didier,Podona, Tchao,Diouf, Ousmane,Lebrun, Philippe,Delarge, Jacques
, p. 3221 - 3234 (2007/10/02)
A series of novel 1,2,4-pyridothiadiazine 1,1-dioxides (1), some of them being pyridyl analogues of the 1,2,4-benzothiadiazine 1,1-dioxide diazoxide (2), were synthesized and selected physicochemical data (pKa, log P′) were collected. By means of spectral (13C NMR, UV) and X-ray data, the most favourable position of the C=N double bond in the thiadiazine ring was discussed. It was concluded that like 1,2,4-benzothiadiazine 1,1-dioxides, 1,2,4-pyridothiadiazine 1,1-dioxides free of an alkyl substituent in the 2-and 4-positions, whatever the nitrogen atom position in the pyridine ring, show predominance of the tautomeric 4H-form.
