163181-19-9

Upstream product

• 163041-41-6 1-benzyl-5-(phenylsulfonyl)-6-<1-benzyloxymethyl-3-hydroxypropyl>-2-piperidone 
• 163041-44-9 (S)-3-((2R,3S)-3-Benzenesulfonyl-1-benzyl-piperidin-2-yl)-3-benzyloxymethoxy-propan-1-ol 
• 163041-43-8 2-(1-benzyloxymethyl-3-hydroxypropyl)-3-(phenylsulfonyl)-N-benzyl-piperidine 

Downstream Products

• 163041-46-1 1-hydroxy-8-(phenylsulfonyl)-indolizidine 
• 163181-20-2 (1S,8S,8aR)-8-Benzenesulfonyl-octahydro-indolizin-1-ol 

Relevant academic research and scientific papers

Stereochemistry of remote dianion addition to imines. Application to the synthesis of (1S, 8aS)-1-hydroxyindolizidine

A stereoselective route to (1S, 8aS)-1-hydroxyindolizidine is reported herein that incorporates as a pivotal step the diastereoselective addition of the dianion of 4-(phenylsulfonyl)butanoic acid (4-PSBA) to a chiral α-benzyloxymethyl imine.