1631985-06-2Relevant academic research and scientific papers
Palladium-catalyzed carbonylation of aryl bromides with n-substituted cyanamides
Lian, Zhong,Friis, Stig D.,Lindhardt, Anders T.,Skrydstrup, Troels
supporting information, p. 1241 - 1245 (2014/06/10)
The palladium(0)-catalyzed three-component coupling reaction of aryl bromides, carbon monoxide, and N-alkyl cyanamides has been developed employing a two-chamber system with ex situ generation of carbon monoxide from a silacarboxylic acid. The reactions proceeded well and were complete with a reaction time of only five hours leading to the corresponding N-alkyl cyanamides in good yields. The methodology was further extended to 13C isotope labeling of the carbonyl group through the use of a 13CO produced from the corresponding 13C-labeled version of the silacarboxylic acid. Georg Thieme Verlag Stuttgart New York.
