163209-37-8

Basic information

• Product Name: 2(S)-(Phenylsulfonamido)-3-[4-(1-piperazinyl)benzamido]propionic acid
• Synonyms: L-750034
• CAS NO: 163209-37-8
• Molecular Formula: C₂₀H₂₄N₄O₅S
• Molecular Weight: 432.50208
• Mol File: 163209-37-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(S)-(Phenylsulfonamido)-3-[4-(1-piperazinyl)benzamido]propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2(S)-(Phenylsulfonamido)-3-[4-(1-piperazinyl)benzamido]propionic acid(163209-37-8)
• EPA Substance Registry System: 2(S)-(Phenylsulfonamido)-3-[4-(1-piperazinyl)benzamido]propionic acid(163209-37-8)

Safety Data

• Hazardous Substances Data: 163209-37-8(Hazardous Substances Data)

Upstream product

• 80518-57-6 ethyl 4-(piperazin-1-yl)benzoate 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 234082-33-8 4-(4-ethoxycarbonylphenyl)piperazine-1-carboxylic acid tert-butyl ester 
• 162046-66-4 4-(4-(1,1-dimethylethoxycarbonyl)piperazin-1-yl)benzoic acid 
• 163210-45-5 4-[4-(2-benzenesulfonylamino-2-tert-butoxycarbonyl-ethylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part 1: Design and synthesis of a lead compound exhibiting αvβ3/ αIIbβ3 dual antagonistic activity

In order to generate novel compounds with integrin α vβ3-antagonistic activity together with antiplatelet activity, tricyclic pharmacophore-based molecules were designed and synthesized. Although piperazine-containing compounds initially prepared were selective αIIbβ3 antagonists, replacement of piperazine with piperidine furnished a potent αvβ3/ αIIbβ3 dual antagonist. Structure-activity relationship (SAR) studies provided clues for further development of tricyclic pharmacophore-based integrin antagonists.