1632156-31-0Relevant articles and documents
Pd-Catalyzed Csp2-H Functionalization of Heteroarenes via Isocyanide Insertion: Concise Synthesis of Di-(Hetero)Aryl Ketones and Di-(Hetero)Aryl Alkylamines
Sharma, Upendra K.,Sharma, Nandini,Xu, Jun,Song, Gonghua,Van Der Eycken, Erik V.
, p. 4908 - 4912 (2015)
We report herein an efficient Pd-catalyzed direct C-H bond functionalization of heteroarenes via an isocyanide insertion strategy for the synthesis of di-(hetero)aryl ketones and di-(hetero)aryl alkylamines. The methodology involves a three component reaction between an azole, a haloarene and an isocyanide resulting in the formation of an imine, which in turn is either hydrolyzed or reduced to get the desired product.