163217-74-1

Basic information

• Product Name: O-HYDROXY ATORVASTATIN LACTONE
• Synonyms: O-HYDROXY ATORVASTATIN LACTONE;5-(4-Fluorophenyl)-N-(2-hydroxyphenyl)-2-(1-Methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxaMide;5-(4-fluorophenyl)-1-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-N-(2-hydroxyphenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxaMide;2-Hydroxy Atorvastatin Lactone(EP);Atorvastatin 2-Hydroxy Lactone;5-(4-Fluorophenyl)-1-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)-ethyl)-N-(2-hydroxyp
• CAS NO: 163217-74-1
• Molecular Formula: C33H33FN2O5
• Molecular Weight: 556.62
• Product Categories: Various Metabolites and Impurities;Metabolites
• Mol File: 163217-74-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 110-112°C
• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• CAS DataBase Reference: O-HYDROXY ATORVASTATIN LACTONE(CAS DataBase Reference)
• NIST Chemistry Reference: O-HYDROXY ATORVASTATIN LACTONE(163217-74-1)
• EPA Substance Registry System: O-HYDROXY ATORVASTATIN LACTONE(163217-74-1)

Safety Data

• Hazardous Substances Data: 163217-74-1(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Different sources of media describe the Uses of 163217-74-1 differently. You can refer to the following data:
1. A metabolite of Atorvastin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia
2. A metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
3. Atorvastatin metabolite

Upstream product

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• 186663-74-1 tert-butyl (2-hydroxyphenyl)carbamate 
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• 265989-39-7 (4R-cis)-1,1-dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(4-benzyloxyphenyl)carbonyl]-1H-pyrrol-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate 
• 265989-40-0 ((4R,6R)-6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester 
• 1346599-89-0 (3R,5R)-7-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester 
• 887355-33-1 4-methyl-3-oxo-N-(2-benzyloxyphenyl)-2-[1-phenyl-2-(4-fluorophenyl)-2-oxoethyl]pentanamide 
• 163217-77-4 4-Methyl-3-oxo-2-[1-phenyl-meth-(Z)-ylidene]-pentanoic acid (2-benzyloxy-phenyl)-amide 
• 265989-31-9 N-(2-(benzyloxy)phenyl)-4-methyl-3-oxopentanamide 
• 4560-41-2 2-benzyloxynitrobenzene 
• 20012-63-9 o-(benzyloxy)aniline 
• 214217-86-4 o-Hydroxyatorvastatin 

Relevant articles and documents

IMPROVED PROCESS FOR THE PREPARATION OF [3R,5R]-2-FLUOROPHENYL-β,δ- DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(2-HYDROXYPHENYLAMINO)- CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID, SODIUM SALT

The present invention relates to an improved process for the preparation of [3R,5R]-2-fluorophenyl-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(2-hydroxyphenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid sodium salt compound of formula- 1 represented by the following structural formula: