1632260-43-5

Basic information

• Product Name: 8-chlorooctyl 2-(2-bromophenyl)-2-diazoacetate
• Synonyms: 8-chlorooctyl 2-(2-bromophenyl)-2-diazoacetate
• CAS NO: 1632260-43-5
• Molecular Weight: 387.704
• Mol File: 1632260-43-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-chlorooctyl 2-(2-bromophenyl)-2-diazoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chlorooctyl 2-(2-bromophenyl)-2-diazoacetate(1632260-43-5)
• EPA Substance Registry System: 8-chlorooctyl 2-(2-bromophenyl)-2-diazoacetate(1632260-43-5)

Safety Data

• Hazardous Substances Data: 1632260-43-5(Hazardous Substances Data)

Upstream product

• 2162-99-4 1,8-dichlorooctane 
• 63071-77-2 potassium 2-bromophenylacetate 
• 1632260-38-8 8-chlorooctyl 2-(2-bromophenyl)acetate 

Relevant articles and documents

Regioselectivity of intramolecular rhodium-catalyzed c-h insertion reactions of α-aryl-α-diazocarboxylates: Influence of the aryl substituent

It was found that α-aryl-α-diazocarboxylates react with variable regioselectivity in intramolecular rhodium-catalyzed C-H insertion reactions. 3-(Trialkoxysilyl)propyl esters underwent a clean cis-γ-lactone formation (62-69%) if the aryl rest was a phenyl group while the analogous α-(2-bromophenyl)-α-diazocarboxylates produced the respective β-lactones. In general β-lactone formation was shown to be the only detectable C-H insertion pathway for the latter substrate class irrespective of the ester substituent. The β-lactone products (eight examples) were obtained in yields of 41-68% with a diastereomeric ratio (dr) of 75:25 to 96:4 in favor of the trans diastereoisomer. The 2-bromo substituent could be displaced by an aryl group in a subsequent Suzuki cross-coupling reaction. Georg Thieme Verlag Stuttgart New York.