163254-41-9

Upstream product

• 762-42-5 dimethyl acetylenedicarboxylate 
• 20989-17-7 (2S)-2-phenylglycinol 
• 163191-47-7 [4S-4α,9α,9aα]-1,6-dioxo-4-phenyloctahydropyrido[2,1-c][1,4]oxazine-9-carboxylic acid methyl ester 
• 163191-46-6 (4S)-1,6-dioxo-4-phenyl-1,3,4,6,7,8-hexahydropyrido[2,1-c][1,4]oxazine-9-carboxylic acid methyl ester 
• 163191-45-5 [(S)-2-Oxo-5-phenyl-morpholin-(3Z)-ylidene]-acetic acid methyl ester 

Downstream Products

• 163254-42-0 [4S-4α,9α,9aβ]-1-oxo-4-phenyloctahydropyrido[2,1-c][1,4]oxazine-9-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Enantioselective synthesis of conformationally restricted analogs of NMDA: cis- and trans-Piperidine-2,3-dicarboxylic acids and methylated derivatives

Various enantiopure stereoisomeric cyclic amino diacids belonging to the 2,3-piperidinedicarboxylic acid series were obtained via an aza-annulation reaction between enamino esters and acryloyl, methacryloyl, or crotonyl chloride. Enantioselective synthese

Neuromediator analogs: Synthesis of cis (2R,3S) and trans (2S,3S)-2,3-piperidine dicarboxylic acids from (2S)-2-phenylglycinol

The cis and trans isomers of 2,3-piperidine dicarboxylic acids were obtained in enantiopure forms from the same chiral inductor: 2-phenylglycinol. This synthesis was mainly based on a δ-lactam formation via Stille's aza-annulation/hydrogenation procedure