163258-14-8

Basic information

• Product Name: 5-(phenylsulfanyl)indole
• Synonyms: 5-(phenylsulfanyl)indole
• CAS NO: 163258-14-8
• Molecular Formula: C₁₄H₁₁NS
• Molecular Weight: 225
• Mol File: 163258-14-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(phenylsulfanyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(phenylsulfanyl)indole(163258-14-8)
• EPA Substance Registry System: 5-(phenylsulfanyl)indole(163258-14-8)

Safety Data

• Hazardous Substances Data: 163258-14-8(Hazardous Substances Data)

Upstream product

• 10075-50-0 5-bromo-1H-indole 
• 108-98-5 thiophenol 
• 496-15-1 1-indoline 
• 128564-66-9 5-bromo-1-triisopropylsilyl-1H-indole 
• 594-19-4 tert.-butyl lithium 
• 882-33-7 diphenyldisulfane 

Downstream Products

• 163258-02-4 3-(1-methyl-1,2,5,6-tetrahydropyrid-4-yl)-5-phenylthioindole 

Relevant articles and documents

Site-Specific Oxidative C-H Chalcogenation of (Hetero)Aryl-Fused Cyclic Amines Enabled by Nanocobalt Oxides

By employing reusable nanocobalt oxides as the catalysts, a site-specific oxidative C-H chalcogenation of (hetero)aryl-fused cyclic amines with various thiols and diselenides is presented for the first time. The reaction proceeds selectively at the sites of the (hetero)aryl rings para to the N atom, and enables access to a wide array of chalcogenyl N-heteroarenes. The merits of the transformation involve high step- and atom-efficiency, excellent substrate and functional compatibility, operational simplicity, and the use of a naturally abundant Co/O2 system. The present work has offered a fundamental basis for the selective synthesis of functional N-heteroarenes from readily available feedstocks.

METHOD FOR PRODUCING THIOETHER COMPOUND

Disclosed is an efficient and widely-applicable method for commercially producing a thioether compound or a thiol compound which is useful as a pharmaceutical product or a production intermediate of a pharmaceutical product. Specifically disclosed is a method for producing a thioether compound represented by the general formula [I] below or a salt thereof. This method is characterized in that a compound represented by the following general formula [III]: [III] (wherein X represents a bromine atom, a chlorine atom or a trifluoromethylsulfonyloxy group, and ring A represents an aryl group or a heteroaryl ring group) or a salt thereof is reacted with a thiol compound represented by the following general formula [II]: [II] or a salt thereof in the presence of a palladium compound such as Pd2(dba)3, a base such as i-Pr2NEt and a phosphorus compound represented by the following formula [AA].

Tryptamine analogues as 5-ht1-like agonists

A compound of structure (I), in which A1 is O, S(O)n in which n is 0, 1 or 2, NR, CH2, or CH(OH); A2 is a bond or CH2 ; or A1 A2 is CH=CH; R is hydrogen or C1-4 alkyl;