163261-08-3Relevant academic research and scientific papers
Basic ethers and process for the preparation thereof
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, (2008/06/13)
Novel basic ether of general formula (I), STR1 wherein R1 and R2 are independently hydrogen, halogen or C1-4 alkoxy, or together they represent a 3,4-methylenedioxy group, R stands for C1-8 alkyl, R3 represents hydrogen, C1-4 alkyl or hydroxy, A is a valency bond or methylene group, R4 and R5 are independently hydrogen, C1-12 alkyl or C1-12 alkenyl, or R4 and R5 form together with the adjacent nitrogen atom 1-pyrrolidinyl, 1-piperidinyl, morpholino or 1-piperazinyl groups, stereo and optically active isomers and their possible mixtures, acid-addition salts and quaternary ammonium derivatives thereof. The basic ethers have antiulceric and anxiolytic activities.
1-(Phenyl)-3-[omega-(amino)-alkoxyimino]-alk-1-ene derivatives, a process for preparing them as well as medicaments containing them and the use of them
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, (2008/06/13)
A subject-matter of the invention are 1-(Phenyl)-3-[ω-(amino)-alkoxyimino]-alk-1-ene derivatives of general formula wherein R1 and R2independently each stands for hydrogen, halogen or a C1 4 alkoxy group or together represent a 3,4-methylenedioxy group, Rstands for C1 8 alkyl, R3represents hydrogen, C1 4 alkyl or hydroxy, R4 and R5independently each represents hydrogen, a C1 12 alkyl group, optionally substituted by hydroxy, or a C2 12 alkenyl or C3 6 cycloalkyl group,óóóor R4 and R5together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocyclic ring, optionally comprising an oxygen, sulfur or a further nitrogen atom, which latter optionally may carry a phenyl, benzyl or C1 4 alkyl substituent, óóóand Arepresents a valency bond or a -CH2-group, as well as stereo and optically active isomers and their mixtures, acid-addition salts and quaternary ammonium derivatives thereof. Furthermore the invention is concerned with a process for preparing these compounds as well as medicaments containing them and the use of them for preparing medicaments, particularly having ulcus and gastric-acid-secretion inhibiting and anxiolytic effects.
