163271-07-6Relevant articles and documents
SUBSTITUTED HETEROCYCLIC INHIBITORS OF PTPN11
-
Paragraph 0223-0224, (2019/11/19)
The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their applica
2-CYANOPYRROLIDINECARBOXAMIDE COMPOUND
-
Page/Page column 65, (2008/06/13)
A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X1 and X2 each is independently lower alkylene; X3 is =CH2, =CHF or =CF2; R1 is substituent, R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.] having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.