163295-70-3

Basic information

• Product Name: (3,5-DICHLORO-PHENYL)-METHANESULFONYL CHLORIDE
• Synonyms: [(3,5-DICHLOROPHENYL)METHYL]SULFONYL CHLORIDE;(3,5-DICHLOROPHENYL)METHYLSULPHONYL CHLORIDE;(3,5-DICHLORO-PHENYL)-METHANESULFONYL CHLORIDE;3,5-Dichloro-ɑ-toluenesufonyl chloride;3,5-Dichloro-^a-toluenesufonyl chloride;3,5-Dichloro-alpha-toluenesufonyl chloride;3,5-Dichloro--toluenesufonyl chloride;3,5-Dichloro-^a-toluenesulfonyl chloride, 96%
• CAS NO: 163295-70-3
• Molecular Formula: C₇H₅Cl₃O₂S
• Molecular Weight: 259.54
• Mol File: 163295-70-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 350.6°Cat760mmHg
• Flash Point: 165.8°C
• Appearance: White to pale yellow/Powder or Solid
• Density: 1.601g/cm³
• Vapor Pressure: 8.81E-05mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (3,5-DICHLORO-PHENYL)-METHANESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-DICHLORO-PHENYL)-METHANESULFONYL CHLORIDE(163295-70-3)
• EPA Substance Registry System: (3,5-DICHLORO-PHENYL)-METHANESULFONYL CHLORIDE(163295-70-3)

Safety Data

• Hazard Codes: C
• Statements: 29-34
• Safety Statements: 8-26-36/37/39-45
• RIDADR: UN3261
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 163295-70-3(Hazardous Substances Data)

Usage

General Description

(3,5-DICHLORO-PHENYL)-METHANESULFONYL CHLORIDE is a chemical compound with the molecular formula C7H6Cl2O2S. It is a reactive and highly toxic compound that is commonly used in the pharmaceutical and chemical industries as a reagent for the synthesis of various organic compounds. It is also used as an intermediate in the production of agrochemicals and in the manufacturing of dyes and pigments. The compound is known for its strong and pungent odor and should be handled with extreme caution due to its potential health hazards. It is important to use proper protective equipment and follow strict safety protocols when working with this compound.

InChI:InChI=1/C7H5Cl3O2S/c8-6-1-5(2-7(9)3-6)4-13(10,11)12/h1-3H,4H2

Upstream product

• 3290-06-0 1,3-dichloro-5-chloromethyl-benzene 
• 138221-06-4 3,5-dichlorobenzylisothiourea hydrochloride 

Downstream Products

• 1445901-64-3 N-[4-(4-acetyl-piperazin-1-yl)-2-fluorobenzyl]-N-cyclobutyl-1-(3,5-dichloro-phenyl)methanesulfonamide 
• 1062085-06-6 C₂₆H₂₇Cl₃N₄O₄S 
• 934292-10-1 (2S,4R)-2-(4-bromo-benzyl)-4-(tert-butyl-dimethyl-silanyloxy)-1-(3,5-dichlorophenylmethanesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester 

Relevant articles and documents

Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties

P2Y12 antagonists are widely used as antiplatelet agents for the prevention and treatment of arterial thrombosis. Based on the scaffold of a known P2Y12 antagonist AZD1283, a series of novel bicyclic pyridine derivatives were designed and synthesized. The cyclization of the ester substituent on the pyridine ring to the ortho-methyl group led to lactone analogues of AZD1283 that showed significantly enhanced metabolic stability in subsequent structure-pharmacokinetic relationship studies. The metabolic stability was further enhanced by adding a 4-methyl substituent to the piperidinyl moiety. Compound 58l displayed potent inhibition of platelet aggregation in vitro as well as antithrombotic efficacy in a rat ferric chloride model. Moreover, 58l showed a safety profile that was superior to what was observed for clopidogrel in a rat tail-bleeding model. These results support the further evaluation of compound 58l as a promising drug candidate.

Process for making an aldehyde

A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.