163295-70-3

Usage

Uses

Used in Pharmaceutical Industry:
(3,5-DICHLORO-PHENYL)-METHANESULFONYL CHLORIDE is used as a reagent for the synthesis of various organic compounds, playing a crucial role in the development of new pharmaceuticals. Its reactivity allows for the creation of diverse chemical entities that can be further utilized in medicinal chemistry.
Used in Chemical Industry:
In the chemical industry, (3,5-DICHLORO-PHENYL)-METHANESULFONYL CHLORIDE is employed as an intermediate in the production of agrochemicals, contributing to the development of effective crop protection agents and other agricultural products.
Used in Dyes and Pigments Manufacturing:
(3,5-DICHLORO-PHENYL)-METHANESULFONYL CHLORIDE is used as a key intermediate in the manufacturing of dyes and pigments, enabling the production of a wide range of colorants for various applications, including textiles, plastics, and printing inks.
Safety Precautions:
Given the compound's high toxicity and strong odor, it is essential to handle (3,5-DICHLORO-PHENYL)-METHANESULFONYL CHLORIDE with extreme care. Proper protective equipment, such as gloves, goggles, and respirators, should be worn at all times during its use. Additionally, strict adherence to safety protocols, including proper storage, disposal, and containment measures, is necessary to minimize the risk of exposure and potential health hazards.

InChI:InChI=1/C7H5Cl3O2S/c8-6-1-5(2-7(9)3-6)4-13(10,11)12/h1-3H,4H2

Upstream product

• 138221-06-4 3,5-dichlorobenzylisothiourea hydrochloride 
• 3290-06-0 1,3-dichloro-5-chloromethyl-benzene 

Downstream Products

• 683812-95-5 methyl 4-{2-[5-chloro-2-(2-{[(3,5-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate 
• 540524-08-1 N-[2-(1-benzhydryl-6-chloro-1H-indol-2-yl)-ethyl]-C-(3,5-dichloro-phenyl)-methanesulfonamide 
• 934292-10-1 (2S,4R)-2-(4-bromo-benzyl)-4-(tert-butyl-dimethyl-silanyloxy)-1-(3,5-dichlorophenylmethanesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 1445901-64-3 N-[4-(4-acetyl-piperazin-1-yl)-2-fluorobenzyl]-N-cyclobutyl-1-(3,5-dichloro-phenyl)methanesulfonamide 

Relevant academic research and scientific papers

Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties

P2Y12 antagonists are widely used as antiplatelet agents for the prevention and treatment of arterial thrombosis. Based on the scaffold of a known P2Y12 antagonist AZD1283, a series of novel bicyclic pyridine derivatives were designed and synthesized. The cyclization of the ester substituent on the pyridine ring to the ortho-methyl group led to lactone analogues of AZD1283 that showed significantly enhanced metabolic stability in subsequent structure-pharmacokinetic relationship studies. The metabolic stability was further enhanced by adding a 4-methyl substituent to the piperidinyl moiety. Compound 58l displayed potent inhibition of platelet aggregation in vitro as well as antithrombotic efficacy in a rat ferric chloride model. Moreover, 58l showed a safety profile that was superior to what was observed for clopidogrel in a rat tail-bleeding model. These results support the further evaluation of compound 58l as a promising drug candidate.

Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis

This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds in the treating or preventing thrombosis in a mammal, or preventing progression of symptoms of thrombosis.

Process for making an aldehyde

A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.