1633819-04-1

Basic information

• Product Name: C₁₂H₇Cl₃N₂O₂
• Synonyms: C₁₂H₇Cl₃N₂O₂
• CAS NO: 1633819-04-1
• Molecular Weight: 317.559
• Mol File: 1633819-04-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₂H₇Cl₃N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₇Cl₃N₂O₂(1633819-04-1)
• EPA Substance Registry System: C₁₂H₇Cl₃N₂O₂(1633819-04-1)

Safety Data

• Hazardous Substances Data: 1633819-04-1(Hazardous Substances Data)

Upstream product

• 1620683-71-7 1-(2,4-dichlorophenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylic acid 
• 1620683-65-9 ethyl 1-(2,4-dichlorophenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate 
• 129493-70-5 3-oxo-2-(2-(2,4-dichlorophenyl)hydrazono)butanoic acid ethyl ester 
• 554-00-7 2,4-Dichloroaniline 

Downstream Products

• 1620683-96-6 1-(2,4-dichlorophenyl)-N-(3-fluoro-4-((6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxamide 
• 1620684-04-9 1-(2,4-dichlorophenyl)-N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxamide 

Relevant articles and documents

Discovery of novel 7-azaindole derivatives bearing dihydropyridazine moiety as c-Met kinase inhibitors

A series of 7-azaindole derivatives bearing the dihydropyridazine scaffold were synthesized and evaluated for their c-Met kinase inhibitory, and antiproliferative activity against 4 cancer cell lines (HT29, A549, H460, U87MG) were evaluated in?vitro. Most compounds showed moderate to excellent potency. Compared to foretinib, the most promising analog 34 (c-Met IC50: 1.06?nM, a multitarget tyrosine kinase inhibitor) showed a 6.4-, 7.8-, and 3.2-fold increase in activity against HT29, A549, and H460?cell lines, respectively. Structure activity relationship studies indicated that mono-EWGs (such as R2?=?F) at 4-position of moiety D was a key factor in improving the antitumor activity.