1633934-99-2

Basic information

• Product Name: 2-methoxy-6-methyl-3,4-diphenylisoquinolin-1(2H)-one
• Synonyms: 2-methoxy-6-methyl-3,4-diphenylisoquinolin-1(2H)-one
• CAS NO: 1633934-99-2
• Molecular Weight: 341.409
• Mol File: 1633934-99-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-methoxy-6-methyl-3,4-diphenylisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-6-methyl-3,4-diphenylisoquinolin-1(2H)-one(1633934-99-2)
• EPA Substance Registry System: 2-methoxy-6-methyl-3,4-diphenylisoquinolin-1(2H)-one(1633934-99-2)

Safety Data

• Hazardous Substances Data: 1633934-99-2(Hazardous Substances Data)

Upstream product

• 99-94-5 p-Toluic acid 
• 874-60-2 4-methyl-benzoyl chloride 
• 25563-06-8 N-methoxy-4-methylbenzamide 
• 501-65-5 diphenyl acetylene 

Relevant articles and documents

Palladium-Nanoparticles-Catalyzed Oxidative Annulation of Benzamides with Alkynes for the Synthesis of Isoquinolones

A novel method to synthesize isoquinolones via oxidative annulation of N-alkoxy benzamides and alkynes using binaphthyl-stabilized palladium nanoparticles (Pd-BNP) as catalyst has been developed. This methodology affords various isoquinolone derivatives in good to excellent yields with high regioselectivities in the presence of air as oxidant. N-Methoxybenzothioamide was also found to undergo oxidative annulation with alkyne successfully and provided a sulfur analogue of isoquinolones in moderate yields. The Pd-BNP catalyst was easily recovered and reused up to four times without any apparent agglomeration. (Figure presented.).

Metal-free iodine(III)-promoted synthesis of isoquinolones

A metal-free oxidative cycloaddition reaction of substituted benzamides and alkynes has been developed for the synthesis of isoquinolones by using bis(trifluoracetoxy)iodobenzene (PIFA) and trifluoroacetic acid (TFA). Under mild conditions, a wide variety of isoquinolones were conveniently prepared via oxidative annulation of simple N-methoxybenzamide and diarylacetylene or aryl/alkyl acetylene derivatives in yields up to 87%.