1634-90-8 Usage
Description
Z-PRO-LEU-OH is a dipeptide compound in the field of biochemistry and pharmaceutical research, composed of two amino acids, proline and leucine, with the amino group of the proline residue protected by a benzyloxycarbonyl (Z) group. This protection is crucial for preventing unwanted reactions during chemical synthesis, making Z-PRO-LEU-OH a valuable tool for understanding the biology and pharmacology of peptide-based compounds.
Usage:
Used in Biochemistry and Pharmaceutical Research:
Z-PRO-LEU-OH is used as a building block for the synthesis of larger peptides, contributing to the development of novel peptide-based drugs and therapeutic agents. Its protected structure allows for controlled and efficient peptide synthesis, enhancing the yield and purity of the final products.
Used in Peptide Synthesis:
Z-PRO-LEU-OH is used as a protected dipeptide in the synthesis of more complex peptide sequences. The benzyloxycarbonyl (Z) group on the proline residue ensures that unwanted side reactions are minimized, allowing for the selective formation of the desired peptide bonds.
Used in Biological Systems Research:
Z-PRO-LEU-OH serves as a model compound for studying the activity and properties of dipeptides in biological systems. Its structure and properties provide insights into the interactions between peptides and their target molecules, as well as their potential biological effects.
Used in Drug Development:
Z-PRO-LEU-OH is used in the development of peptide-based drugs, where its protected structure allows for the synthesis of bioactive peptides with specific therapeutic properties. Z-PRO-LEU-OH can be further modified or incorporated into larger peptide sequences to target specific diseases or conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1634-90-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,3 and 4 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1634-90:
(6*1)+(5*6)+(4*3)+(3*4)+(2*9)+(1*0)=78
78 % 10 = 8
So 1634-90-8 is a valid CAS Registry Number.
1634-90-8Relevant articles and documents
Total synthesis of cyclic heptapeptide Rolloamide B
Khatib, Mirna El,Elagawany, Mohamed,?ali?kan, Eray,Davis, Emily Faith,Faidallah, Hassan M.,El-Feky, Said A.,Katritzky, Alan R.
, p. 2631 - 2633 (2013/05/08)
The first total synthesis of Rolloamide B, a cyclic proline-enriched heptapeptide, is reported. This work features solution phase benzotriazole-mediated peptide synthesis ligating native amino acids. The Royal Society of Chemistry 2013.
Synthesis of L-prolyl-leucyl-α-aminoisobutyryl-α-amino-isobutyryl-glutamyl-valinol and proof of identity with the isolated C-terminal fragment of trichotoxin A-40
Bruckner,Jung
, p. 1677 - 1699 (2007/10/02)
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