163449-68-1

Basic information

• Product Name: 3-(4-fluorophenyl)-1-(3-hydroxyphenyl)-2-propen-1-one
• Synonyms: 3-(4-fluorophenyl)-1-(3-hydroxyphenyl)-2-propen-1-one
• CAS NO: 163449-68-1
• Molecular Formula: C15H11FO2
• Molecular Weight: 242.2450432
• Mol File: 163449-68-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-fluorophenyl)-1-(3-hydroxyphenyl)-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-fluorophenyl)-1-(3-hydroxyphenyl)-2-propen-1-one(163449-68-1)
• EPA Substance Registry System: 3-(4-fluorophenyl)-1-(3-hydroxyphenyl)-2-propen-1-one(163449-68-1)

Safety Data

• Hazardous Substances Data: 163449-68-1(Hazardous Substances Data)

Upstream product

• 121-71-1 3-Hydroxyacetophenone 
• 459-57-4 4-fluorobenzaldehyde 

Relevant articles and documents

Anti-cholinesterase activity of chalcone derivatives: Synthesis, in vitro assay and molecular docking study

Background: Chalcones, originated from natural product, have been broadly studied their biological activity against various proteins which at the molecular level, are responsible for the progress of the diseases in cancer (e.g. kinases), inflammation (oxi

COMPOUNDS AND METHODS FOR TREATING OR PREVENTING HEART FAILURE

The present invention relates to the discovery of novel compounds that can be used to treat and/or prevent heart failure in a subject. In certain embodiments, the compounds of the invention are sulfide: quinone oxidoreductase (SQOR) inhibitors. In other e

Inhibition of LPS-stimulated ROS production by fluorinated and hydroxylated chalcones in RAW 264.7 macrophages with structure-activity relationship study

Based on the importance of the previous fluorinated and/or hydroxylated chalcones studies, thirty-six compounds were designed as phenyl or hydroxyphenyl bearing fluoro, trifluoromethyl or trifluoromethoxy phenyl propenones and synthesized by applying modified Claisen-Schmidt condensation reaction as a single step. Inhibitory effects of the synthesized compounds on ROS production stimulated by LPS in RAW 264.7 macrophage were evaluated. Structure-activity relationship (SAR) study revealed that the compounds possessing para-hydroxyphenyl group combined with meta-fluoro or meta-trifluoromethyl phenyl group, and meta/para-hydroxyphenyl group combined with ortho-trifluoromethoxyphenyl group have an essential role in inhibiting the LPS-stimulated ROS production in RAW 264.7 macrophages. The most significant inhibitory effect on LPS-stimulated ROS production in RAW 264.7 macrophages was observed in compound 30 that possessed para-hydroxyphenyl group along with ortho-trifluoromethoxyphenyl group.