163457-23-6

Basic information

• Product Name: 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE
• Synonyms: 3,3-DIFLUOROPYRROLIDINE HCL;3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE;Pyrrolidine, 3,3-difluoro-, hydrochloride (1:1);3,3-Difluoropyrrolidine h...;1-Aza-3,3-difluorocyclopentane;3,3-Difluoropyrrolidine hydrochloride;3,3-Difluoropyrrolidine hydrochloride 97%
• CAS NO: 163457-23-6
• Molecular Formula: C₄H₇F₂N*ClH
• Molecular Weight: 143.56
• EINECS: -0
• Product Categories: pharmacetical;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrrolidines;PyrrolidinesHeterocyclic Building Blocks;Heterocycles;Miscellaneous Reagents;Building Blocks;C4 to C10;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles
• Mol File: 163457-23-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 128-130°C
• Boiling Point: 84.4 °C at 760 mmHg
• Flash Point: 4.8 °C
• Appearance: /
• Vapor Pressure: 72.6mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Hygroscopic
• CAS DataBase Reference: 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE(163457-23-6)
• EPA Substance Registry System: 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE(163457-23-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT, HYGROSCOPIC
• Hazardous Substances Data: 163457-23-6(Hazardous Substances Data)

Usage

Chemical Properties

Beige solid

Uses

3,3-Difluoropyrrolidine hydrochloride can be used as a building block in the synthesis of: Triazole substituted prolyl difluoropyrrolidines as potential inhibitors of dipeptidyl peptidase-4. Dual leucine zipper kinase (DLK) inhibitors.It can be also used as a reactant in the preparation of cyclic and acyclic β-aminofluoroalkenes via allylic amination using the Pd catalyst.

InChI:InChI=1/C4H7F2N.ClH/c5-4(6)1-2-7-3-4;/h7H,1-3H2;1H

Upstream product

• 162970-49-2 3,3-difluoropyrrolidin-2-one 
• 195447-25-7 3,3-Difluoro-1-pyrrolidinecarboxylic acid,1,1-dimethylethyl ester 
• 862416-37-3 1-benzyl-3,3-difluoro-pyrrolidine; hydrochloride 

Downstream Products

• 1186230-62-5 pentafluorophenyl 4-[(3,3-difluoro-1-pyrrolidinyl)methyl]benzenesulfonate 
• 1187649-56-4 (4-{6-[(S)-1-tert-butoxycarbonylamino-3-(3,3-difluoro-pyrrolidin-1-yl)-3-oxo-propyl]-3-oxo-2,3-dihydro-pyridazin-4-yl}-phenyl)-carbamic acid methyl ester 
• 1186514-71-5 5-(3,3-difluoropyrrolidine-1-carbonyl)-4'-methyl-N-((2-methylpyrimidin-5-yl)methyl)biphenyl-3-carboxamide 
• 1200131-33-4 4-((3,3-difluoropyrrolidin-1-yl)methyl)phenylboronic acid 
• 1219978-48-9 (Z)-4-(3,3-difluoropyrrolidin-1-yl)-2-fluoro-1-phenylbut-2-en-1-ol 
• 1452782-88-5 (R)-1-(4-fluorophenyl)-6-[4-(3,3-difluoropyrrolidin-1-yl)benzenesulfonyl]-4a-(methoxymethyl)-4,4a,5,6,7,8-hexahydro-1H-1,2,6-triaza-cyclopenta[b]naphthalene 
• 1429241-52-0 1-(2,4-dichlorophenyl)-4-((3,3-difluoropyrrolidin-1-yl)-methyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)-ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide 
• 1432509-51-7 methyl 4-((3-((3,3-difluoropyrrolidin-1-yl)methyl)-4-oxo-1,2,3,4-tetrahydrocarbazol-9-yl)methyl)benzoate 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING

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NOVEL BETULINIC SUBSTITUTED AMIDE DERIVATIVES AS HIV INHIBITORS

The present invention relates to novel betulinic substituted amide compounds of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y, Z1, Z2, Z3 and are Formula (II) as defined herein. The invention novel betulinic substituted amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.

PYRAZOLE DERIVATIVE

A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.