16349-40-9

Basic information

• Product Name: 2,6-Benzothiazolediamine,N2,N2-dimethyl-(9CI)
• Synonyms: 2,6-Benzothiazolediamine,N2,N2-dimethyl-(9CI)
• CAS NO: 16349-40-9
• Molecular Formula: C9H11N3S
• Molecular Weight: 193.26874
• Product Categories: BENZOTHIAZOLE
• Mol File: 16349-40-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 342.2±34.0 °C(Predicted)
• Appearance: /
• Density: 1.319±0.06 g/cm3(Predicted)
• PKA: 6.01±0.10(Predicted)
• CAS DataBase Reference: 2,6-Benzothiazolediamine,N2,N2-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Benzothiazolediamine,N2,N2-dimethyl-(9CI)(16349-40-9)
• EPA Substance Registry System: 2,6-Benzothiazolediamine,N2,N2-dimethyl-(9CI)(16349-40-9)

Safety Data

• Hazardous Substances Data: 16349-40-9(Hazardous Substances Data)

Usage

General Description

2,6-Benzothiazolediamine, N2, N2-dimethyl-(9CI) is a chemical compound that belongs to the class of benzothiazole derivatives. It is also known by its Chemical Abstracts Service (CAS) number 19291-56-4. 2,6-Benzothiazolediamine,N2,N2-dimethyl-(9CI) is commonly used in the manufacturing of rubber products, such as tires, as a vulcanization accelerator. It works by promoting the crosslinking of rubber molecules, which enhances the physical properties and durability of the rubber material. Additionally, it is also used in the production of dyes, pharmaceuticals, and other organic compounds. However, it is important to handle this chemical with care, as it may be harmful if ingested or inhaled and can cause irritation to the skin and eyes when in contact.

Upstream product

• 6285-57-0 2-amino-6-nitrobenzothiazole 
• 136-95-8 2-amino-benzthiazole 
• 2407-11-6 2-chloro-6-nitrobenzothiazole 
• 3507-21-9 N,N-dimethyl-6-nitrobenzo[d]thiazol-2-amine 

Relevant articles and documents

NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF

The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

Design, synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino)quinoline-3-carbonitrile derivatives

A series of new 6,7-disubstituted-4-(benzothiazol-6-ylamino)quinoline-3-carbonitrile derivatives (12a-l) were synthesized. The cytotoxicity of 12 new compounds was evaluated in AGS, HepG2 and HT-29 cell lines. The results showed that compounds 12g, 12h, 12i, 12k and 12l displayed more potent cytotoxic activities than Bosutinib, compound 12l exhibited the most potent antitumor activity among the tested compounds.

In vitro activities of position 2 substitution-bearing 6-nitro- and 6-amino-benzothiazoles and their corresponding anthranilic acid derivatives against Leishmania infantum and Trichomonas vaginalis.

6-Nitro- and 6-amino-benzothiazoles bearing different chains in position 2 and their corresponding anthranilic acid derivatives were investigated for their in vitro antiparasitic properties against parasites of the species Leishmania infantum and Trichomonas vaginalis compared to their toxicity towards human monocytes. Biological investigations established that the antiprotozoal properties depended greatly on the chemical structure of the position 2 substitution-bearing group. Compound C1, 2-[(2-chloro-benzothiazol-6-yl) amino] benzoic acid, demonstrated an interesting antiproliferative activity towards parasites of the species T. vaginalis, while compound C11, 2-([2-[(2-hydroxyethyl) amino]-benzothiazol-6-yl] amino) benzoic acid, exhibited a promising activity against parasites of the species L. infantum in their intracellular amastigote form. Additional experiments established that compound C11, which was poorly toxic against the promastigote and the extracellular amastigote forms of the parasite, could improve host-protective mechanisms against Leishmania by preventing parasite internalization by macrophages and stimulating NO production, by means of a mechanism synergistically enhanced by the presence of gamma interferon.