16351-50-1

Basic information

• Product Name: Thiazolo[4,5-f]quinoline, 2-(methylamino)- (8CI)
• Synonyms: Thiazolo[4,5-f]quinoline, 2-(methylamino)- (8CI)
• CAS NO: 16351-50-1
• Molecular Formula: C11H9N3S
• Molecular Weight: 215.27426
• Product Categories: BENZOTHIAZOLE
• Mol File: 16351-50-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 393.4±34.0 °C(Predicted)
• Appearance: /
• Density: 1.406±0.06 g/cm3(Predicted)
• PKA: 3.40±0.50(Predicted)
• CAS DataBase Reference: Thiazolo[4,5-f]quinoline, 2-(methylamino)- (8CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazolo[4,5-f]quinoline, 2-(methylamino)- (8CI)(16351-50-1)
• EPA Substance Registry System: Thiazolo[4,5-f]quinoline, 2-(methylamino)- (8CI)(16351-50-1)

Safety Data

• Hazardous Substances Data: 16351-50-1(Hazardous Substances Data)

Upstream product

• 1255211-32-5 5-(N'-methylthioureido)quinoline 

Relevant articles and documents

An expedient synthesis of novel 2-substituted thiazolo[4,5-f]isoquinolines/ quinolines and benzo[1,2-d:4,3-d']bisthiazoles and their potential as inhibitors of COX-1 and COX-2

An efficient, general synthesis of 2-substituted thiazolo[4,5-f] isoquinolines, thiazolo[4,5-f]-quinolines and benzo[1,2-d:4,3-d']bisthiazoles has been accomplished from 5-nitroisoquinoline/quinoline and 6-nitrobenzothiazole, respectively, and all the products have been thoroughly identified spectroscopically (IR, 1H and 13C NMR, LR/HR EI/FAB/ESI-MS). The synthesis of thiazolo[4,5-f]isoquinolines constitutes the first synthesis of this class of heteroarenes. Eighteen compounds, covering all three types, were screened for inhibition of COX-1 and COX-2, and some of them showed moderate activities. ARKAT-USA, Inc.