163563-22-2Relevant academic research and scientific papers
A new linker for glucuronylated anticancer prodrugs
Rivault, Freddy,Tranoy-Opalinski, Isabelle,Gesson, Jean-Pierre
, p. 675 - 682 (2007/10/03)
The synthesis, enzymatic hydrolysis and self decomposition of model glucuronylated prodrugs, incorporating a new linker with different aryl substituents, have been studied. Determination of kinetic parameters (V max, Km and t1/2
New synthetic routes to 3-, 5-, and 6-aryl-2-chloropyridines
Church,Trust,Albright,Powell
, p. 3750 - 3758 (2007/10/02)
The efficient synthesis of 3-, 5-, and 6-aryl-2-chloropyridines via the facile preparation of 5-(dimethylamino)aryl-substituted pentadienyl nitriles and cyclization with hydrochloric acid is described. This approach allows for the introduction of other electron-withdrawing substituents on the pyridine ring as well as the preparation of the desired unsubstituted arylpyridines. Some differences in the rates of cyclization of the pentadienyl nitriles as well as the yields of chloropyridines were observed that depended on the position and degree of substitution in the aryl substituent. The arylpentadienyl nitriles 5 and 6 could also be converted directly into the corresponding 2-aminopyridines.
Method for inducing tillering utilizing certain pyridine-1-oxides
-
, (2008/06/13)
This invention relates to a method of inducing tillering in cereal plants using certain 5-phenyl-3-pyridinecarboxylate compounds, to certain of the compounds themselves, to a process for preparing these compounds, and to agricultural compositions containing them. The compounds are also useful as intermediates for preparing other of the compounds.
