163563-71-1

Upstream product

• 60514-48-9 1,2-dioctanoyl-sn-glycerol 
• 108549-21-9 benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite 

Downstream Products

• 1212821-99-2 (+)-1D-1-(1,2-dioctanoyl-sn-glycerol-3-phospho)-2,3,4,5,6-penta-O-benzyl-myo-inositol 
• 377752-81-3 Octanoic acid (R)-2-[hydroxy-((1S,2R,3R,4S,5S,6R)-2,4,6-tris-butyryloxy-3,5-bis-phosphonooxy-cyclohexyloxy)-phosphoryloxy]-1-octanoyloxymethyl-ethyl ester 
• 796883-91-5 Octanoic acid (R)-2-{benzyloxy-[(1S,2R,3R,4S,5S,6R)-2,4,6-tris-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-5-hydroxy-cyclohexyloxy]-phosphoryloxy}-1-octanoyloxymethyl-ethyl ester 
• 377752-80-2 Octanoic acid (R)-2-{benzyloxy-[(1S,2S,3S,4S,5R,6R)-3,4-bis-(bis-benzyloxy-phosphoryloxy)-2,5,6-tris-butyryloxy-cyclohexyloxy]-phosphoryloxy}-1-octanoyloxymethyl-ethyl ester 
• 377752-78-8 Octanoic acid (R)-2-{benzyloxy-[(1S,2R,3R,4S,5S,6R)-3,5-bis-(bis-benzyloxy-phosphoryloxy)-2,4,6-tris-butyryloxy-cyclohexyloxy]-phosphoryloxy}-1-octanoyloxymethyl-ethyl ester 

Relevant academic research and scientific papers

A synthesis of dioctanoyl phosphatidylinositol

A synthesis of the naturally occurring enantiomer of phosphatidylinositol is reported. A resolution strategy, using camphor as a chiral auxiliary is employed to obtain the desired, enantiomerically pure, inositol derivative. Dioctanoyl lipid chains are appended to the molecule, which are shorter than the naturally occurring lipid chains, providing the molecule with enhanced water solubility.

Intracellular mediators: Synthesis of L-α-phosphatidyl-D-myo-inositol 3,4,5-trisphosphate and glyceryl ether analogs

L-α-Phosphatidyl-D-myo-inositol 3,4,5-trisphosphate (3,4,5-PIP3), the most prominent member of a new class of intracellular second messengers, and two ether analogs were conveniently prepared from the differentially functionalized D-myo-inosito