163565-84-2

Upstream product

• 98-01-1 furfural 
• 163660-13-7 (R)-2-(2-Allyloxy-3-bromo-phenyl)-4-hydroxy-cyclopent-2-enone 
• 170868-78-7 (+/-)-2-(2-allyloxy-3-bromophenyl)-4-hydroxycyclopent-2-enone 
• 72764-02-4 2,6-dibromophenol allyl ether 
• 41138-67-4 (1E,3S)-1-iodo-3-(tert-butyldimethylsiloxy)-1-octene 
• 163565-83-1 (R)-2-(2-Allyloxy-3-bromo-phenyl)-4-(tert-butyl-dimethyl-silanyloxy)-cyclopent-2-enone 
• 163565-82-0 Acetic acid (R)-3-(2-allyloxy-3-bromo-phenyl)-4-oxo-cyclopent-2-enyl ester 
• 170868-76-5 (2-Allyloxy-3-bromo-phenyl)-furan-2-yl-methanol 

Relevant academic research and scientific papers

An Efficient Approach to Optically Active Benzoprostacyclins by a Two-component Coupling Process

A highly efficient and practical synthesis of enantiomerically pure benzoprostacyclins, chemically stable and therapeutically useful prostaglandin I2 analogues, is developed which includes an efficient preparation of 2--4-siloxycyclopent-2-en-1-one 3 in optically active form and the conjugate addition of ω side-chains onto 3 followed by cyclization to the key intermediate (1R,2R,3'S)-2-endo-siloxy-1-exo-(3'-siloxyalk-1-enyl)-3a,8b-cis-2,3,3a,8b-tetrahydro-1H-5-bromocyclopentabenzofuran 4.