16357-81-6Relevant academic research and scientific papers
Part 4. Fused Pyrimidines. Annelation Using Formamide to Synthesize 2,4-Disubstituted-PyrimidoPyrimidines
Delia, Thomas J.,Niedzinski, Jill
, p. 1421 - 1423 (2007/10/02)
A one-step synthesis of 2,4-disubstituted-pyrimidopyrimidines has been investigated.Cyclization of 6-amino-2,4-disubstituted-pyrimidines with formamide as solvent and reagent affords the title compounds in 50-70percent yield.Strongly electron-donating groups are required.Based on model compounds, a pathway for the cyclization is suggested.The method is an improvement on previous methods of synthesis, albeit a limited one.
