163593-87-1Relevant academic research and scientific papers
Synthesis of New Substituted Quinolizidines as Potential Inhibitors of Ergosterol Biosynthesis.
Godard, Alain,Lamour, Philippe,Ribereau, Pierre,Queguiner, Guy
, p. 3247 - 3264 (1995)
Carbocationic species (High Energy Intermediates) have been postulated as intermediates in the course of enzymatic synthesis of ergosterol.Protonated aza-analogues of the sterol are thus potential inhibitors.The synthesis of substituted quinolizidines (3) is reported. 4-Methoxy-2,3-dimethylpyridine (4) was metalated and reacted with substituted 3-chloropropanal to build the 1-methyl-2-quinolizidinone.The lateral chain was prepared via a Wittig-Horner reaction.
