163615-17-6

Basic information

• Product Name: 2-METHYL-2-TRIFLUOROMETHYLCYCLOHEXANONE
• Synonyms: 2-METHYL-2-TRIFLUOROMETHYLCYCLOHEXANONE
• CAS NO: 163615-17-6
• Molecular Formula: C8H11F3O
• Molecular Weight: 180.17
• Mol File: 163615-17-6.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-METHYL-2-TRIFLUOROMETHYLCYCLOHEXANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-2-TRIFLUOROMETHYLCYCLOHEXANONE(163615-17-6)
• EPA Substance Registry System: 2-METHYL-2-TRIFLUOROMETHYLCYCLOHEXANONE(163615-17-6)

Safety Data

• Hazardous Substances Data: 163615-17-6(Hazardous Substances Data)

Upstream product

• 2314-97-8 iodotrifluoromethane 
• 19980-33-7 6-methyl-1-trimethylsiloxycyclohex-1-ene 
• 19980-35-9 1-trimethylsilyloxy-2-methyl-1-cyclohexene 
• 129946-88-9 Umemoto's reagent 
• 583-60-8 2-Methylcyclohexanone 

Relevant articles and documents

Radical trifluoromethylation of ketone silyl enol ethers by activation with dialkylzinc

(Chemical Equation Presented) The radical trifluoromethylation of ketone silyl enol ethers gave α-CF3 ketones in good yields with wide scope of the ketonic substrates including acyclic ketones and cyclopentanone. The use of dialkylzinc to activ

Dialkylzinc-aceelerated α-trifluoromethylation of carbonyl compounds catalyzed by late-transition-metal complexes

Trifiuoromethylation of ketone silyl enol ethers is found to be significantly accelerated by late-transition-metal catalysts and dialkylzincs to give α-trifluoromethyl ketones in good yields. Addition of dialkylzinc is the key to the high yielding α-trifl

Mechanistic studies on α-trifluoromethylation of ketones via silyl enol ethers and its application to other carbonyl compounds

(Chemical Equation Presented) Synthesis of α-CF3 carbonyl compounds has been recognized to be difficult up to now because the polarization of CF3δ--Iδ+ is opposite to that of CH3δ+-Iδ-, and this makes it difficult to introduce CF3+ unit to enolates. We recently reported an effective R-trifluoromethylation of ketones by using Et 2Zn with Rh catalyst, but the mechanism has not fully been cleared. Now, we carried out the detailed mechanistic studies and found the involvement of a highly reactive alkylrhodium complex which derived from Et2Zn and RhCl(PPh3)3 in this α-trifluoromethylation. Furthermore, this α-trifluoromethylation was applied to other types of carbonyl compounds in good yields.

Radical trifluoromethylation of ketone Li enolates

It has generally been believed that highly basic Li enolates cannot be applied as substrates for radical trifluoromethylation due to defluorination of the α-CF3 product. However, Li enolates can be in fact employed for radical trifluoromethylat