1636166-33-0

Upstream product

• 1636166-30-7 methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate 
• 1636166-29-4 methyl 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-4-carboxylate 
• 1112178-31-0 methyl-6-chloro-2-methylpyrimidine-4-carboxylate 
• 1636166-32-9 tert-butyl 4-(6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carbonyl)piperazine-1-carboxylate 
• 1636166-31-8 6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid 

Downstream Products

• 1636166-34-1 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4(methylsulfonyl)piperazin-1-yl)methanone 
• 1636166-35-2 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((2,4-dichlorophenyl)sulfonyl)piperazin-1-yl)methanone 
• 1636166-36-3 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((2,3-dichlorophenyl)sulfonyl)piperazin-1-yl)methanone 
• 1636166-37-4 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((2,6-dichlorophenyl)sulfonyl)piperazin-1-yl)methanone 
• 1636166-38-5 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((3-fluoro-4-methylphenyl)sulfonyl)piperazin-1-yl)methanone 
• 1636166-39-6 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)methanone 
• 1636166-40-9 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((2,5-dimethoxyphenyl)sulfonyl)piperazin-1-yl)methanone 

Relevant academic research and scientific papers

Synthesis, antibacterial, anthelmintic and anti-inflammatory studies of novel methylpyrimidine sulfonylpiperazine derivatives

A strategic synthesis of novel methylpyrimidine sulfonyl piperazines involving Suzuki coupling was designed and pharmacological activities of the compounds were evaluated. Reactions were carried out under conventional method and show good functional group transformations and high yields. Structures of the newly synthesized compounds were established by infrared spectroscopy (IR), 1H and 13C nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS) and elemental analysis. The compounds were tested for in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus bacterial strains, anthelmintic activity using Pheretima posthuma and anti-inflammatory activity involving carrageenan induced rat paw edema model. Some compounds were proven to be potent pharmacophores.