163619-04-3

Basic information

• Product Name: Fmoc-D-Trp(Boc)-OH
• Synonyms: N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-IN-TERT-BUTYL-OXYCARBONYL-D-TRYPTOPHAN;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-IN-T-BUTYLOXYCARBONYL-D-TRYPTOPHAN;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-IN-T-BUTOXYCARBONYL-D-TRYPTOPHAN;N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-NIN-T-BUTYLOXYCARBONYL-D-TRYPTOPHAN;N-ALPHA-FMOC-N-IN-TERT-BOC-D-TRYPTOPHAN;Fmoc-D-Trp(Boc)-OH >=95.0% (HPLC);N-alpha-(((9H-fluoren-9-yl)methoxy)carbonyl)-1-(tert-butoxycarbonyl)-D-tryptophan;1-[(1,1-Dimethylethoxy)carbonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-tryptophan
• CAS NO: 163619-04-3
• Molecular Formula: C31H30N2O6
• Molecular Weight: 526.58
• Product Categories: Amino Acids;Tryptophan [Trp, W];Fmoc-Amino Acids and Derivatives;Fmoc-Amino acid series
• Mol File: 163619-04-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.289 g/cm³
• Refractive Index: 1.632
• Storage Temp.: 2-8°C
• PKA: 3.71±0.10(Predicted)
• BRN: 7062970
• CAS DataBase Reference: Fmoc-D-Trp(Boc)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-D-Trp(Boc)-OH(163619-04-3)
• EPA Substance Registry System: Fmoc-D-Trp(Boc)-OH(163619-04-3)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 163619-04-3(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Fmoc-D-Trp(Boc)-OH, is an amino acid derivative used in peptide chemistry.

InChI:InChI=1/C31H30N2O6/c1-31(2,3)39-30(37)33-17-19(20-10-8-9-15-27(20)33)16-26(28(34)35)32-29(36)38-18-25-23-13-6-4-11-21(23)22-12-5-7-14-24(22)25/h4-15,17,25-26H,16,18H2,1-3H3,(H,32,36)(H,34,35)/t26-/m1/s1

Upstream product

• 1604-49-5 methyl (2S)-3-(1H-indol-3-yl)-2-(trifluoroacetamido)propanoate 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 146645-63-8 (2S)-2-amino-3-(1-tert-butoxycarbonylindol-3-yl)propanoic acid 
• 2717-76-2 (S)-N-benzyloxycarbonyl-L-tryptophan methyl ester 
• 643751-42-2 N-carbobenzyloxy-1-tert-butoxycarbonyl-L-tryptophan methyl ester 
• 96238-70-9 1-tert-butoxycarbonyl-L-tryptophane methyl ester 
• 73-22-3 L-Tryptophan 
• 4299-70-1 L-tryptophan methyl ester 
• 83451-16-5 (S)-tert-butyl 2-(hydroxyamino)propanoate 
• 1019691-72-5 C₃₇H₃₇N₃O₅S 

Downstream Products

• 157610-37-2 H-Ala-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH₂ 

Relevant articles and documents

COMPOUND FOR PREPARATION OF ANTIBODY-PAYLOAD CONJUGATE AND USE THEREOF

The present application relates to a novel linker for use in bioconjugation, comprising two or more electrophilic carbon atoms of a carbonyl group, and a click chemistry functional group and, more specifically, to a linker through which a compound, a peptide, and/or a protein can be directly and/or indirectly linked by a substitution reaction to a desired target molecule, that is, a target molecule.

DIPHENYLMETHANE COMPOUND

Compounds having a diphenylmethane skeleton are superior in broad utility and stability, and are useful as a protecting reagent (anchor) of amino acid and/or peptide in the liquid phase synthesis and the like of a peptide having a C-terminal etc., which are of a carboxamide(-CONHR)-type, and in organic synthetic reaction methods (particularly peptide liquid phase synthetic methods), and may be contained in a kit for peptide liquid phase synthesis.

Controlled drug delivery system using the conjugation of drug to biodegradable polyester

The present invention relates to the molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect. Moreover, the high loading efficiency of hydrophilic drugs can be achieved.