163680-80-6Relevant articles and documents
Practical synthesis of T-3761, (S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyr ido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
Todo,Takagi,Iino,Hayashi,Takata,Kuroda,Momonoi,Narita
, p. 2629 - 2632 (2007/10/02)
An economical 11-step synthesis of T-3761 (1), a new quinolone antibacterial agent discovered by us, has been developed. Commercially available 2,3,4,5-tetrafluorobenzoic acid (2) has been transformed to 4-(1-acetaminocyclopropyl)-2,3,5-trifluorobenzoic a