16370-58-4Relevant articles and documents
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Dreyfus et al.
, p. 7027 (1977)
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Convenient and efficient syntheses of N6-and N 4-substituted adenines and cytosines and their 2-deoxyribosides
Adamska, Ewelina,Barciszewski, Jan,Markiewicz, Wojciech T.
, p. 861 - 871 (2013/02/23)
Convenient and efficient methods of the synthesis of N6-and N4-substituted derivatives of adenine and cytosine and their 2-deoxyribosides were developed. The reactions of either unprotected nucleobases (adenine, cytosine) or unprotected 2-deoxyribosides with aryl or alkyl aldehydes give corresponding Schiff bases that can be reduced to the target title compounds with high overall yields. In the case of aryl aldehydes the imine derivatives are obtained in the presence of methoxides in methanol and reduced with sodium borohydride. The corresponding reactions with alkyl aldehydes require the use of acetic acid and borane dimethyl sulfide complex instead.
Process for preparing N6,9-disubstituted adenine
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, (2008/06/13)
A process for preparing N6, 9-disubstituted adenines which comprises reacting a metal salt of N6 -substituted adenine with a benzyl halide compound, preferably in the presence of a phase transfer catalyst. According to the process, the N6,9-disubstuted adenines can be obtained in high yields and good selectivity.
