163706-61-4

Basic information

• Product Name: Phosphonic acid, P,P'-(dichloromethylene)bis-, compd. with N,N-dibutyl-1-butanamine (1:1)
• Synonyms: Phosphonic acid, P,P'-(dichloromethylene)bis-, compd. with N,N-dibutyl-1-butanamine (1:1);Phosphonic acid, P,P'-(dichloromethylene)bis-, compd. with N,N-dibutyl-1-butanamine;(Dichloromethylene)bis(phosphonic acid) - N,N-dibutyl-1-butanamine (1:1)
• CAS NO: 163706-61-4
• Molecular Formula: C13H31Cl2NO6P2
• Molecular Weight: 430.241862
• EINECS: -0
• Mol File: 163706-61-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: Phosphonic acid, P,P'-(dichloromethylene)bis-, compd. with N,N-dibutyl-1-butanamine (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, P,P'-(dichloromethylene)bis-, compd. with N,N-dibutyl-1-butanamine (1:1)(163706-61-4)
• EPA Substance Registry System: Phosphonic acid, P,P'-(dichloromethylene)bis-, compd. with N,N-dibutyl-1-butanamine (1:1)(163706-61-4)

Safety Data

• Hazardous Substances Data: 163706-61-4(Hazardous Substances Data)

Usage

Uses

(Dichloromethylene)bis[phosphonic acid] mono(tributylamine) salt can be used as a reactant in the synthetic preparation of uracil nucleotide derivatives and analogs

Upstream product

• 102-82-9 tributyl-amine 
• 10595-91-2 bisodium clodronate 
• 10596-22-2 tetraisopropyl dichloromethylenebisphosphonate 

Downstream Products

• 163706-06-7 cangrelor 

Relevant articles and documents

Synthesis and structure-activity relationship of uracil nucleotide derivatives towards the identification of human P2Y6 receptor antagonists

P2Y6 receptor (P2Y6-R) is involved in various physiological and pathophysiological events. With a view to set rules for the design of UDP-based reversible P2Y6-R antagonists as potential drugs, we established structure-activity relationship of UDP analogues, bearing modifications at the uracil ring, ribose moiety, and the phosphate chain. For instance, C5-phenyl- or 3-NMe-uridine-5′-α,β-methylene-diphosphonate, 16 and 23, or lack of 2′-OH, in 12-15, resulted in loss of both agonist and antagonist activity toward hP2Y6-R. However, uridylyl phosphosulfate, 19, selectively inhibited hP2Y6-R (IC50 112 μM) versus P2Y2/4-Rs. In summary, we have established a comprehensive SAR for hP2Y6-R ligands towards the development of hP2Y6-R antagonists.

Synthesis of AZT 5′-triphosphate mimics and their inhibitory effects on HIV-1 reverse transcriptase

In search of active nucleoside 5′-triphosphate mimics, we have synthesized a series of AZT triphosphate mimics (AZT P3Ms) and evaluated their inhibitory effects on HIV-1 reverse transcriptase as well as their stability in fetal calf serum and in CEM cell

Process for preparing methylene bisphosphonic and salts

A process for the preparation of salts of substituted or unsubstituted methylene bisphosphonic acids by hydrolysing the corresponding acid ester with hydrochloric acid, removing water from the acid azeotropically prior to addition of an amine or a base to