163719-81-1 Usage
Description
1,2,4-OXADIAZOLE-5-CARBOXYLIC ACID, 3-(4-FLUOROPHENYL)-, ETHYL ESTER is a synthetic organic compound that serves as a crucial building block in the pharmaceutical industry. It is a derivative of the bioactive oxadiazole ring system, which is frequently incorporated into drug molecules to enhance their pharmacological activities. The ethyl ester form of this compound is particularly advantageous in drug development due to its capacity to improve the oral bioavailability and solubility of drug compounds. The presence of the fluorophenyl group in its structure may further contribute to its pharmacological properties and biological activity, making it a valuable intermediate for the production of pharmaceuticals and other biologically active compounds.
Uses
Used in Pharmaceutical Industry:
1,2,4-OXADIAZOLE-5-CARBOXYLIC ACID, 3-(4-FLUOROPHENYL)-, ETHYL ESTER is used as a key intermediate in the synthesis of various drugs for its ability to enhance the pharmacological activities of drug molecules. The incorporation of this compound into drug molecules can improve their oral bioavailability and solubility, which are critical factors in drug efficacy and safety.
Used in Drug Development:
As a building block in drug development, 1,2,4-OXADIAZOLE-5-CARBOXYLIC ACID, 3-(4-FLUOROPHENYL)-, ETHYL ESTER is utilized for its potential to improve the overall performance of drug compounds. Its role in enhancing solubility and bioavailability is essential in the optimization of drug delivery and absorption, leading to more effective therapeutic agents.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1,2,4-OXADIAZOLE-5-CARBOXYLIC ACID, 3-(4-FLUOROPHENYL)-, ETHYL ESTER is employed as a versatile compound for the exploration of new chemical entities with potential therapeutic applications. Its unique structural features, including the oxadiazole ring and fluorophenyl group, offer opportunities for the design and synthesis of novel bioactive molecules targeting various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 163719-81-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,7,1 and 9 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 163719-81:
(8*1)+(7*6)+(6*3)+(5*7)+(4*1)+(3*9)+(2*8)+(1*1)=151
151 % 10 = 1
So 163719-81-1 is a valid CAS Registry Number.
163719-81-1Relevant articles and documents
Design, synthesis and biological evaluation of new Axl kinase inhibitors containing 1,3,4-oxadiazole acetamide moiety as novel linker
Xu, Congjun,Han, Yufei,Xu, Sicong,Wang, Ruxin,Yue, Ming,Tian, Yu,Li, Xiaofan,Zhao, Yanfang,Gong, Ping
, (2019/12/09)
Using the principle of bioisosteric replacement, we present a structure-based design approach to obtain new Axl kinase inhibitors with significant activity at the kinase and cellular levels. Through a stepwise structure-activity relationships exploration, a series of 6,7-disubstituted quinoline derivatives, which contain 1,3,4-oxadiazol acetamide moiety as novel Linker, were ultimately synthesized with Axl as the primary target. Most of them exhibited moderate to excellent activity, with IC50 values ranging from 0.032 to 1.54 μM against the tested cell lines. Among them, the most promising compound 47e, as an Axl kinase inhibitor (IC50 = 10 nM), shows remarkable cytotoxicity against A549, HT-29, PC-3, MCF-7, H1975 and MDA-MB-231 cell lines. More importantly, 47e also shows a significant inhibitory effect on EGFR-TKI resistant NSCLC cell lines H1975/gefitinib. Meanwhile, this study provides a novel type of linker for Axl kinase inhibitors, namely 1,3,4-oxadiazol acetamide moiety, which is out of the scope of the “5- atoms role ".
