163726-68-9

Upstream product

• 163726-58-7 3-(1-benzylpiperidin-4-yl)-1-(2,3-dihydrobenzo<1,4>dioxin-6-yl)-3-hydroxypropan-1-one 
• 2879-20-1 1,4-benzodioxan-6-yl methyl ketone 
• 22065-85-6 N-benzyl-4-formylpiperidine 

Relevant academic research and scientific papers

Design and Synthesis of 1-Heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one Derivatives as Potent, Selective Acetylcholinesterase Inhibitors

Herein is described the synthesis and structure-activity relationship of a novel series of aromatic and heteroaromatic 3-(1-benzyl-4-piperidinyl)propan-1-one derivatives that display potent and selective inhibition of the enzyme acetylcholinesterase (AChE

Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block

A series benzylpiperidinium and benzylpyridinium quaternary salts have been synthesised and tested for inhibition of acetylcholinesterase and reversal of neuromuscular block induced by vecuronium. Several potent reversal agents have been identified and their haemodynamic effects measured.