1637436-89-5Relevant academic research and scientific papers
Highly enantioselective carbonyl-ene reactions of 2,3-diketoesters: Efficient and atom-economical process to functionalized chiral α-hydroxy-β-ketoesters
Truong, Phong M.,Zavalij, Peter Y.,Doyle, Michael P.
, p. 6468 - 6472 (2014/06/24)
Carbonyl-ene reactions of 2,3-diketoesters catalyzed by [Cu{(S,S)-tBu-box}](SbF6)2 [box=bis(oxazoline)] generate chiral α-functionalized α-hydroxy-β-ketoesters in up to 94% yield and 97% ee. The 2,3-diketoesters are conveniently accessed from the corresponding α-diazo-β-ketoester, and a catalyst loading as low as 1.0 mol% can be achieved.
