163756-69-2Relevant academic research and scientific papers
Synthesis of 5-substituted-3,3-dimethyl-2-pyrrolidinones: "Quat" chiral auxiliaries
Davies, Stephen G.,Doisneau, Gilles J. -M.,Prodger, Jeremy C.,Sanganee, Hitesh J.
, p. 2369 - 2372 (2007/10/02)
The synthesis of a series of chiral auxiliaries, 5-substituted-3,3-dimethyl-2-pyrrolidinones, "quats", from L-glutamic acid is described. Efficient regeneration of the chiral auxiliaries from their N-pivaloyl derivatives is readily achieved with LiOH in THF-water at 20°C.
