1637569-04-0

Basic information

• Product Name: 2-(3-bromophenyl)-5,6,7-trihydroxy-4H-chromen-4-one
• Synonyms: 2-(3-bromophenyl)-5,6,7-trihydroxy-4H-chromen-4-one
• CAS NO: 1637569-04-0
• Molecular Weight: 349.137
• Mol File: 1637569-04-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(3-bromophenyl)-5,6,7-trihydroxy-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-bromophenyl)-5,6,7-trihydroxy-4H-chromen-4-one(1637569-04-0)
• EPA Substance Registry System: 2-(3-bromophenyl)-5,6,7-trihydroxy-4H-chromen-4-one(1637569-04-0)

Safety Data

• Hazardous Substances Data: 1637569-04-0(Hazardous Substances Data)

Upstream product

• 61592-69-6 (E)-3-(3-Bromo-phenyl)-acryloyl chloride 
• 14473-91-7 3-bromocinnamic acid 
• 1372702-71-0 C₁₈H₁₇BrO₅ 
• 1372702-76-5 2-(3-bromophenyl)-5,6,7-trimethoxy-4H-chromen-4-one 

Relevant articles and documents

COMPOSITION AND METHOD FOR TREATING OR PREVENTING INFLUENZA VIRUS INFECTION

The present invention provides a pharmaceutical composition and method for treating or preventing influenza virus infection in a subject comprising administering the subject with a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of compounds provided in this invention. In addition, the prevent invention provides new compounds for treating or preventing influenza virus infection.

Synthesis and anti-influenza activities of novel baicalein analogs

A series of novel flavones derivatives were synthesized based on modification of the active ingredients of a traditional Chinese medicine Scutellaria baicalensis GEORGI and screened for anti-influenza activity. The synthetic baicalein (flavone) analogs, especially with the B-rings substituted with bromine atoms, were much more potent than oseltamivir or ribavirin against H1N1 Tamiflu-resistant (H1N1 TR) virus and usually with more favorable selectivity. The most promising were 5b, 5c, 6b and 6c, all displaying an 50% effective concentration (EC50) at around 4.0-4.5 μM, and a selective index (SI=50% cytotoxic concentration (CC50)/EC 50)>70. For seasonal H3N2-infected influenza virus, both 5a and 5b with SI >17.3 indicated superior to ribavirin. The flavonoids having both not-naturally-occurring bromo-substituted B-rings and appropriate hydroxyls positioning on the A-rings might be critical in determining the activity and selectivity against H1N1-Tamiflu-resistant infected influenza viruses.