1637595-59-5Relevant academic research and scientific papers
Gold-Catalyzed Cyclisation by 1,4-Dioxidation
Claus, Vanessa,Molinari, Lise,Büllmann, Simon,Thusek, Jean,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.
, p. 9385 - 9389 (2019)
Amide-substituted diynes were cyclized in the presence of a cationic gold catalyst and an external nucleophile leading to 1-indenones and 1-iminoindenones. The electron-donating features of the nitrogen atom enable the formation of a reactive ketene iminium ion, which can be trapped by either diphenyl sulfoxide or anthranil as nucleophiles in a subsequent oxidation step, providing substituted inden-1-on-3-carboxamides.
