1637633-31-8

Basic information

• Product Name: C₁₇H₃₀N₂O
• Synonyms: C₁₇H₃₀N₂O
• CAS NO: 1637633-31-8
• Molecular Weight: 278.438
• Mol File: 1637633-31-8.mol

Chemical Properties

• CAS DataBase Reference: C₁₇H₃₀N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₃₀N₂O(1637633-31-8)
• EPA Substance Registry System: C₁₇H₃₀N₂O(1637633-31-8)

Safety Data

• Hazardous Substances Data: 1637633-31-8(Hazardous Substances Data)

Upstream product

• 1637633-42-1 C₁₂H₁₇ClO₂ 
• 15111-96-3 (S)-(4-(prop-1-en-2-yl)cyclohex-1-en-1-yl)methyl acetate 
• 536-59-4 (-)-perillyl alcohol 
• 18031-40-8 (S)-(-)-perillaldehyde 

Relevant articles and documents

Perilla alcohol derivative and its preparation and use

The invention belongs to the technical field of medicine, and relates to a series of perilla alcohol derivatives disclosed as Formula I, and preparation and application thereof. The invention also relates to pharmaceutically acceptable salts and solvates of the perilla alcohol derivatives, and a pharmaceutical composition containing the perilla alcohol derivatives or pharmaceutically acceptable salts thereof as active components, which can be used for treating cancers. The perilla alcohol derivatives and pharmaceutical salts thereof have favorable anticancer activity. The preparation method is simple and feasible, and is easy to operate.

Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives

Two series of amino-modified derivatives of (S)-perillyl alcohol were designed and synthesized using (S)-perillaldehyde as the starting material. These derivatives showed increased antiproliferative activity in human lung cancer A549 cells, human melanoma A375-S2 cells and human fibrosarcoma HT-1080 cells comparing with that of (S)-perillyl alcohol. Among these derivatives, compounds VI5 and VI7 were the most potent agents, with the IC50s below 100 μM. It was demonstrated that the antiproliferative effect of VI5 was mediated through the induction of apoptosis in A549 cells.