1637648-91-9Relevant academic research and scientific papers
Effective synthesis of 6-substituted 7H-tetrazolo[5,1-b][1,3,4]thiadiazines via a one-pot condensation/nitrosation/azide-tetrazole tautomerism reaction sequence
Kulikov, Alexander S.,Epishina, Margarita A.,Fershtat, Leonid L.,Romanova, Anna A.,Makhova, Nina N.
supporting information, p. 3998 - 4002 (2017/09/26)
A new, simple, and general method for the synthesis of 6-R-7H-tetrazolo[5,1-b][1,3,4]thiadiazines (R = Ar, Het, Alk) has been developed. The described method is based on the one-pot condensation of α-haloketones with thiocarbohydrazide, nitrosation of the formed hydrazinylthiadiazine using NaNO2/HCl, and intramolecular cyclization of the nitrosation product via azide-tetrazole tautomerism. Spectroscopic and structural investigations revealed that the azide-tetrazole equilibrium is completely shifted to the tetrazole form both in solution and the solid state.
Facile synthesis of some novel 6-alkyl or aryl-7H-tetrazolo[5,1-b][1,3,4] thiadiazine
Eftekhar, Melika,Eshghi, Hossein,Rahimizadeh, Mohammad,Bakavoli, Mehdi,Saberi, Sattar
, p. 365 - 367 (2014/07/08)
New bis-heterocyclic thiadiazine derivatives containing a tetrazole nucleus have been synthesised by simple, high yielding routes and characterised by FT-IR, 1H NMR, 13C NMR and mass spectral analysis. The key step in the construction of the sixsubstituted 7H-tetrazolo[5,1-b][1,3,4]thiadiazine derivatives involved the cyclocondensation of sodium 1-amino-1H-tetrazole-5- thiolate with a-haloketones. The radical scavenging activity of the new tetrazolothiadiazines was also investigated.
