163765-44-4

Basic information

• Product Name: (R)-4-Boc-2-methylpiperazine
• Synonyms: (R)-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-N-BOC-2-METHYLPIPERAZINE;(R)-N4-BOC-2-METHYLPIPERAZINE;TERT-BUTYL (R)-3-METHYL-1-PIPERAZINECARBOXYLATE;(R)-4-N-BOC-2-METHYLPIPERAZINE;(R)-4-BOC-2-METHYLPIPERAZINE;(R)-3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-1-BOC-3-METHYLPIPERAZINE
• CAS NO: 163765-44-4
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 200.28
• Product Categories: Piperazine series;pharmacetical;Piperaizine;Piperazines
• Mol File: 163765-44-4.mol
• Article Data: 17

Chemical Properties

• Melting Point: 40-45 °C
• Boiling Point: 268.7 °C at 760 mmHg
• Flash Point: 223 °F
• Appearance: White/Crystalline Powder
• Density: 0.997 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.52±0.40(Predicted)
• CAS DataBase Reference: (R)-4-Boc-2-methylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-Boc-2-methylpiperazine(163765-44-4)
• EPA Substance Registry System: (R)-4-Boc-2-methylpiperazine(163765-44-4)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41-36/37/38
• Safety Statements: 26-39-37/39
• WGK Germany: 3
• F: 10-34
• Hazardous Substances Data: 163765-44-4(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

(R)-4-Boc-2-methylpiperazine is a reagent used in organic synthesis. Used in the synthesis of orally bioavailable inhibitors of 11-β-hydroxysteroid

Upstream product

• 120737-59-9 3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 75336-86-6 (2R)-methylpiperazine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1242138-67-5 (R)-tert-butyl 4-(4-acetylphenylsulfonyl)-3-methylpiperazine-1-carboxylate 
• 1032820-95-3 (R)-1-methanesulfonyl-2-methyl-piperazine 
• 1191918-48-5 C₃₄H₄₈N₄O₄Si 
• 1191918-77-0 C₂₂H₂₈Cl₂N₄O₂ 
• 1191918-78-1 C₂₃H₃₁ClN₄O₂ 
• 1191918-79-2 C₂₃H₂₈ClF₃N₄O₂ 
• 1191919-41-1 C₂₃H₂₉F₃N₄O₄ 
• 1089686-77-0 (R)-1-(4-bromophenyl)-4-tert-butoxycarbonyl-2-methylpiperazine 
• 1288977-20-7 (1S,2R,3R)-1-[(R)-4-(4-cyclopropylphenyl)-3-methylpiperazine-1-sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid hydrochloride 
• 1288977-21-8 (1S,2R,3R)-1-[(R)-4-(5-cyanothiophen-2-yl)-3-methylpiperazine-1-sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid 
• 1288977-59-2 (1S,2R,3R)-1-[(R)-4-(5-cyanothiophen-2-yl)-3-methylpiperazine-1-sulfonylamino]-2,3-dimethyl-2-phenylcyclopropane-1-carboxylic acid 
• 1288978-01-7 (R)-1-tert-butoxycarbonyl-4-(4-cyclopropylphenyl)-3-methylpiperazine 
• 1288978-19-7 (R)-1-(4-cyclopropylphenyl)-2-methylpiperazine 
• 1240914-03-7 4-{(1S, 2S)-2-[((R)-4-cyclobutyl-2-methylpiperazin-1-yl)carbonyl]-cyclopropyl}-benzamide 

Relevant articles and documents

Preparation method of tyrosine kinase inhibitor AZD3759

The invention provides a preparation method of a tyrosine kinase inhibitor AZD3759, and relates to the field of medicinal chemistry. The preparation method comprises the following steps: by taking 3,4-dihydro-7-methoxy-4-oxoquinazoline-6-alcohol acetate as a raw material, carrying out a chlorination reaction and a hydrolysis reaction to obtain 4-chloro-7-methoxyquinazoline-6-alcohol (a compound 3); taking (R)-(-)-2-methylpiperazine as a raw material, and obtaining (R)-4-chlorocarbonyl-3-tert-butyl formate (compound 6) through a nucleophilic addition-elimination reaction and a chloroformylation reaction; carrying out an esterification reaction on the compound 3 and the compound 6 to obtain a compound 7; carrying out a Boc removal reaction and a methylation reaction on the compound 7 to obtain a compound 9; and carrying out alkylation reaction on the compound 9 and 2-fluoro-3-chloroaniline to obtain AZD3759. The method has the advantages of cheap and accessible raw materials and lower cost; sodium cyanoborohydride is not used in the reaction process, so that the method is more environment-friendly and is beneficial to industrial large-scale production.

1,4-Palladium Shift/C(sp3)-H Activation Strategy for the Remote Construction of Five-Membered Rings

1,n-Metal shift is an elegant alternative approach enabling the functionalization of remote C-H bonds from simple precursors. In this work, we report a novel and simple Pd0-catalyzed domino reaction involving 1,4-palladium shift and C(sp3)-H activation and leading to (fused) five-membered rings. This method allowed access to a broad range of valuable arylidene γ-lactams and indanones and was applied to the formal synthesis of (-)-pyrrolam.

CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.